小鼠中的T淋巴细胞与对肌肉锥虫免疫的转移
T lymphocytes and the transfer of immunity to Trypanosoma musculi in mice.
作者信息
Pouliot P, Viens P, Targett G A
出版信息
Clin Exp Immunol. 1977 Mar;27(3):507-11.
Abstract
Trypanosoma musculi produces a resolving infection in mice and the immune response is thymus dependent. Spleen cells from immune and from uninfected mice were transferred to T cell-deprived mice and restored their ability to control the infection, the immune cells being effective most rapidly. Treatment of the cells in vitro with anti-theta serum did not impair their ability to restore immunocompetence and it is proposed that, though T-cell dependent, the immune response is effected by theta- cells.
摘要
鼠锥虫可在小鼠体内引发自限性感染，且免疫反应依赖胸腺。将免疫小鼠和未感染小鼠的脾细胞转移至T细胞缺失的小鼠体内，可恢复其控制感染的能力，免疫细胞的作用最为迅速。用抗θ血清在体外处理这些细胞，并不损害其恢复免疫活性的能力，因此有人提出，尽管免疫反应依赖T细胞，但却是由θ细胞介导的。
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