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1
Inhibition of murine cytomegalovirus lung infection and interstitial pneumonitis by acyclovir and 9-(1,3-dihydroxy-2-propoxymethyl)guanine.阿昔洛韦和9-(1,3-二羟基-2-丙氧甲基)鸟嘌呤对小鼠巨细胞病毒肺部感染和间质性肺炎的抑制作用
Antimicrob Agents Chemother. 1985 Aug;28(2):172-5. doi: 10.1128/AAC.28.2.172.
2
Activity of 9-(1,3-dihydroxy-2-propoxymethyl)guanine compared with that of acyclovir against human, monkey, and rodent cytomegaloviruses.9-(1,3-二羟基-2-丙氧基甲基)鸟嘌呤与阿昔洛韦对人、猴和啮齿动物巨细胞病毒的活性比较。
Antimicrob Agents Chemother. 1985 Aug;28(2):240-5. doi: 10.1128/AAC.28.2.240.
3
The relation of viral replication to interstitial pneumonitis in murine cytomegalovirus lung infection.小鼠巨细胞病毒肺部感染中病毒复制与间质性肺炎的关系。
J Infect Dis. 1985 Mar;151(3):454-8. doi: 10.1093/infdis/151.3.454.
4
Successful treatment of murine cytomegalovirus disease does not prevent latent virus infection.成功治疗鼠巨细胞病毒疾病并不能预防潜伏病毒感染。
J Lab Clin Med. 1986 Aug;108(2):155-60.
5
In vitro and in vivo activities of phosphate derivatives of 9-(1,3-dihydroxy-2-propoxymethyl)-guanine against cytomegaloviruses.9-(1,3-二羟基-2-丙氧基甲基)鸟嘌呤的磷酸盐衍生物对巨细胞病毒的体外和体内活性
Antiviral Res. 1986 Aug;6(5):299-308. doi: 10.1016/0166-3542(86)90025-2.
6
9-(1-3-Dihydroxy-2-propoxymethyl)guanine prevents death but not immunity in murine cytomegalovirus-infected normal and immunosuppressed BALB/c mice.9-(1-3-二羟基-2-丙氧甲基)鸟嘌呤可预防鼠巨细胞病毒感染的正常和免疫抑制BALB/c小鼠死亡，但不能预防免疫抑制。
Antimicrob Agents Chemother. 1987 Jul;31(7):1017-20. doi: 10.1128/AAC.31.7.1017.
7
Antiviral effect of 9-(1,3-dihydroxy-2-propoxymethyl)guanine against cytomegalovirus infection in a guinea pig model.9-(1,3-二羟基-2-丙氧甲基)鸟嘌呤对豚鼠模型巨细胞病毒感染的抗病毒作用
Antiviral Res. 1987 Jan;7(1):11-23. doi: 10.1016/0166-3542(87)90035-0.
8
Interstitial pneumonitis during murine cytomegalovirus infection and graft-versus-host reaction: effect of ganciclovir therapy.鼠巨细胞病毒感染和移植物抗宿主反应期间的间质性肺炎：更昔洛韦治疗的效果
J Infect Dis. 1988 Dec;158(6):1391-4. doi: 10.1093/infdis/158.6.1391.
9
Aerosol administration of antiviral agents to treat lung infection due to murine cytomegalovirus.雾化吸入抗病毒药物治疗小鼠巨细胞病毒引起的肺部感染。
J Infect Dis. 1988 Feb;157(2):327-31. doi: 10.1093/infdis/157.2.327.
10
Prolonged inhibitory effect of 9-(1,3-dihydroxy-2-propoxymethyl)guanine against replication of Epstein-Barr virus.9-(1,3-二羟基-2-丙氧甲基)鸟嘌呤对爱泼斯坦-巴尔病毒复制的持久抑制作用
J Virol. 1984 Apr;50(1):50-5. doi: 10.1128/JVI.50.1.50-55.1984.

引用本文的文献

1
Ganciclovir transiently attenuates murine cytomegalovirus-associated renal allograft inflammation.更昔洛韦一过性减轻小鼠巨细胞病毒相关性肾移植炎症反应。
Transplantation. 2011 Oct 15;92(7):759-66. doi: 10.1097/TP.0b013e31822c6e89.
2
Complete sequence and genomic analysis of rhesus cytomegalovirus.恒河猴巨细胞病毒的全序列及基因组分析
J Virol. 2003 Jun;77(12):6620-36. doi: 10.1128/jvi.77.12.6620-6636.2003.
3
Sequence and transcriptional analysis of the guinea pig cytomegalovirus UL97 homolog.豚鼠巨细胞病毒UL97同源物的序列和转录分析。
Virus Genes. 1997;15(3):255-64. doi: 10.1023/a:1007988705909.
4
Suppression of herpes simplex virus type 1 (HSV-1)-induced pneumonia in mice by inhibition of inducible nitric oxide synthase (iNOS, NOS2).通过抑制诱导型一氧化氮合酶（iNOS，NOS2）抑制小鼠单纯疱疹病毒1型（HSV-1）诱导的肺炎。
J Exp Med. 1997 May 5;185(9):1533-40. doi: 10.1084/jem.185.9.1533.
5
Analysis of the complete DNA sequence of murine cytomegalovirus.小鼠巨细胞病毒全DNA序列分析
J Virol. 1996 Dec;70(12):8833-49. doi: 10.1128/JVI.70.12.8833-8849.1996.
6
Human cytomegalovirus in a SCID-hu mouse: thymic epithelial cells are prominent targets of viral replication.人巨细胞病毒在重症联合免疫缺陷-人源化小鼠中的情况：胸腺上皮细胞是病毒复制的主要靶标。
Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):104-8. doi: 10.1073/pnas.90.1.104.
7
Antiviral agents.抗病毒药物。
Med Clin North Am. 1988 May;72(3):691-715. doi: 10.1016/s0025-7125(16)30766-0.
8
Ganciclovir prophylaxis for cochlear pathophysiology during experimental guinea pig cytomegalovirus labyrinthitis.更昔洛韦对实验性豚鼠巨细胞病毒性迷路炎期间耳蜗病理生理学的预防作用。
Antimicrob Agents Chemother. 1988 Jun;32(6):865-72. doi: 10.1128/AAC.32.6.865.
9
9-(1-3-Dihydroxy-2-propoxymethyl)guanine prevents death but not immunity in murine cytomegalovirus-infected normal and immunosuppressed BALB/c mice.9-(1-3-二羟基-2-丙氧甲基)鸟嘌呤可预防鼠巨细胞病毒感染的正常和免疫抑制BALB/c小鼠死亡，但不能预防免疫抑制。
Antimicrob Agents Chemother. 1987 Jul;31(7):1017-20. doi: 10.1128/AAC.31.7.1017.
10
Effect of 2'-nor-cyclic GMP against guinea pig cytomegalovirus infection.2'-去甲环鸟苷酸对豚鼠巨细胞病毒感染的影响。
Antimicrob Agents Chemother. 1989 Sep;33(9):1563-8. doi: 10.1128/AAC.33.9.1563.

本文引用的文献

1
Overview of acyclovir pharmacokinetic disposition in adults and children.阿昔洛韦在成人和儿童体内的药代动力学处置概述。
Am J Med. 1982 Jul 20;73(1A):186-92. doi: 10.1016/0002-9343(82)90088-2.
2
Treatment of cytomegaloviral pneumonia with high-dose acyclovir and human leukocyte interferon.大剂量阿昔洛韦与人类白细胞干扰素治疗巨细胞病毒性肺炎
J Infect Dis. 1983 Sep;148(3):557-62. doi: 10.1093/infdis/148.3.557.
3
The pathogenesis of pneumonitis due to murine cytomegalovirus.鼠巨细胞病毒所致肺炎的发病机制
J Infect Dis. 1982 Sep;146(3):388-96. doi: 10.1093/infdis/146.3.388.
4
Treatment of cytomegalovirus pneumonia with high-dose acyclovir.大剂量阿昔洛韦治疗巨细胞病毒肺炎
Am J Med. 1982 Jul 20;73(1A):249-56. doi: 10.1016/0002-9343(82)90100-0.
5
Effect of acyclovir treatment on acute and chronic murine cytomegalovirus infection.阿昔洛韦治疗对急性和慢性小鼠巨细胞病毒感染的影响。
Am J Med. 1982 Jul 20;73(1A):132-7. doi: 10.1016/0002-9343(82)90078-x.
6
Thymidine kinase not required for antiviral activity of acyclovir against mouse cytomegalovirus.阿昔洛韦对小鼠巨细胞病毒的抗病毒活性无需胸苷激酶。
J Virol. 1981 Sep;39(3):889-93. doi: 10.1128/JVI.39.3.889-893.1981.
7
Efficacy of acyclovir against mouse cytomegalovirus in vivo.阿昔洛韦在体内对小鼠巨细胞病毒的疗效。
Antimicrob Agents Chemother. 1981 Aug;20(2):275-8. doi: 10.1128/AAC.20.2.275.
8
Toxicity and efficacy of human leukocyte interferon for treatment of cytomegalovirus pneumonia after marrow transplantation.人白细胞干扰素治疗骨髓移植后巨细胞病毒肺炎的毒性与疗效
J Infect Dis. 1980 May;141(5):555-62. doi: 10.1093/infdis/141.5.555.
9
Role of macrophages in resistance to murine cytomegalovirus.巨噬细胞在抵抗小鼠巨细胞病毒中的作用。
Infect Immun. 1974 Dec;10(6):1383-90. doi: 10.1128/iai.10.6.1383-1390.1974.
10
The relation of viral replication to interstitial pneumonitis in murine cytomegalovirus lung infection.小鼠巨细胞病毒肺部感染中病毒复制与间质性肺炎的关系。
J Infect Dis. 1985 Mar;151(3):454-8. doi: 10.1093/infdis/151.3.454.

阿昔洛韦和9-(1,3-二羟基-2-丙氧甲基)鸟嘌呤对小鼠巨细胞病毒肺部感染和间质性肺炎的抑制作用

Inhibition of murine cytomegalovirus lung infection and interstitial pneumonitis by acyclovir and 9-(1,3-dihydroxy-2-propoxymethyl)guanine.

作者信息

Shanley J D, Morningstar J, Jordan M C

出版信息

Antimicrob Agents Chemother. 1985 Aug;28(2):172-5. doi: 10.1128/AAC.28.2.172.

DOI:10.1128/AAC.28.2.172
PMID:3010835
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC180213/
Abstract

We compared the effects of acyclovir (ACV) and 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG) on murine cytomegalovirus (MCMV) replication in lung and salivary gland tissues, the evolution of interstitial pneumonitis in vivo, and MCMV replication in mouse embryo cells in vitro. As measured by plaque reduction, ACV was more active than DHPG in vitro. In vivo, whether administered orally by gastric intubation or in the drinking water, or subcutaneously, DHPG was more effective than ACV in reducing MCMV titers in lung or salivary gland tissues. This was true in both normal and cyclophosphamide-treated mice. Neither drug was able to prevent MCMV interstitial pneumonitis, despite substantial reductions in virus titer, but both drugs reduced the severity of the pneumonitis.

摘要

我们比较了阿昔洛韦（ACV）和9-（1,3-二羟基-2-丙氧甲基）鸟嘌呤（DHPG）对肺和唾液腺组织中鼠巨细胞病毒（MCMV）复制的影响、体内间质性肺炎的演变以及体外小鼠胚胎细胞中MCMV的复制情况。通过蚀斑减少法测定，在体外ACV比DHPG更具活性。在体内，无论是通过胃管口服给药、加入饮用水中给药还是皮下给药，DHPG在降低肺或唾液腺组织中的MCMV滴度方面都比ACV更有效。在正常小鼠和环磷酰胺处理的小鼠中均是如此。尽管病毒滴度大幅降低，但两种药物都无法预防MCMV间质性肺炎，但两种药物都减轻了肺炎的严重程度。