阿昔洛韦和9-(1,3-二羟基-2-丙氧甲基)鸟嘌呤对小鼠巨细胞病毒肺部感染和间质性肺炎的抑制作用
Inhibition of murine cytomegalovirus lung infection and interstitial pneumonitis by acyclovir and 9-(1,3-dihydroxy-2-propoxymethyl)guanine.
作者信息
Shanley J D, Morningstar J, Jordan M C
出版信息
Antimicrob Agents Chemother. 1985 Aug;28(2):172-5. doi: 10.1128/AAC.28.2.172.
Abstract
We compared the effects of acyclovir (ACV) and 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG) on murine cytomegalovirus (MCMV) replication in lung and salivary gland tissues, the evolution of interstitial pneumonitis in vivo, and MCMV replication in mouse embryo cells in vitro. As measured by plaque reduction, ACV was more active than DHPG in vitro. In vivo, whether administered orally by gastric intubation or in the drinking water, or subcutaneously, DHPG was more effective than ACV in reducing MCMV titers in lung or salivary gland tissues. This was true in both normal and cyclophosphamide-treated mice. Neither drug was able to prevent MCMV interstitial pneumonitis, despite substantial reductions in virus titer, but both drugs reduced the severity of the pneumonitis.
摘要
我们比较了阿昔洛韦（ACV）和9-（1,3-二羟基-2-丙氧甲基）鸟嘌呤（DHPG）对肺和唾液腺组织中鼠巨细胞病毒（MCMV）复制的影响、体内间质性肺炎的演变以及体外小鼠胚胎细胞中MCMV的复制情况。通过蚀斑减少法测定，在体外ACV比DHPG更具活性。在体内，无论是通过胃管口服给药、加入饮用水中给药还是皮下给药，DHPG在降低肺或唾液腺组织中的MCMV滴度方面都比ACV更有效。在正常小鼠和环磷酰胺处理的小鼠中均是如此。尽管病毒滴度大幅降低，但两种药物都无法预防MCMV间质性肺炎，但两种药物都减轻了肺炎的严重程度。
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