阿昔洛韦在体内对小鼠巨细胞病毒的疗效。
Efficacy of acyclovir against mouse cytomegalovirus in vivo.
作者信息
Wingard J R, Bender W J, Saral R, Burns W H
出版信息
Antimicrob Agents Chemother. 1981 Aug;20(2):275-8. doi: 10.1128/AAC.20.2.275.
Abstract
Acyclovir reduced mortality and organ virus titers in mice inoculated intraperitoneally with 10 50% lethal doses of mouse cytomegalovirus. This susceptibility to acyclovir of a herpesvirus which lacks thymidine kinase is surprising. Alternative phosphorylating enzymes may account for this susceptibility.
摘要
阿昔洛韦降低了经腹腔接种10个50%致死剂量小鼠巨细胞病毒的小鼠的死亡率和器官病毒滴度。一种缺乏胸苷激酶的疱疹病毒对阿昔洛韦的这种敏感性令人惊讶。其他磷酸化酶可能是造成这种敏感性的原因。
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