Tsusaki B E, Kanda S, Huang L
Biochem Biophys Res Commun. 1986 Apr 14;136(1):242-6. doi: 10.1016/0006-291x(86)90900-9.
Incorporation of 1-oleoyl-2-acetylglycerol (OAG) into multilamellar liposomes composed of egg phosphatidylethanolamine (PE) and arachidonic acid (AA) resulted in a significant enhancement of superoxide release by guinea pig neutrophils when compared to free OAG. OAG incorporated into liposomes containing phosphatidylcholine and arachidonic acid were generally less effective than free OAG. The potency of the liposomes correlates well with the ability of the liposomes to undergo lipid mixing at acidic pH. The enhanced effect of liposome-associated OAG could be related to exposure to an acidic environment in the endosomes/lysosomes once liposomes are endocytosed by neutrophils.
与游离的1-油酰基-2-乙酰甘油（OAG）相比，将1-油酰基-2-乙酰甘油（OAG）掺入由鸡蛋磷脂酰乙醇胺（PE）和花生四烯酸（AA）组成的多层脂质体中，可显著增强豚鼠中性粒细胞释放超氧化物的能力。掺入含有磷脂酰胆碱和花生四烯酸的脂质体中的OAG通常比游离的OAG效果差。脂质体的效力与脂质体在酸性pH下进行脂质混合的能力密切相关。脂质体相关的OAG的增强作用可能与中性粒细胞内吞脂质体后，OAG暴露于内体/溶酶体的酸性环境有关。
