Program for Bioengineering, Seoul National University, Seoul, 08826, Republic of Korea.
Lab Chip. 2018 Sep 11;18(18):2686-2709. doi: 10.1039/c8lc00285a.
Microphysiological systems have emerged in the last decade to provide an alternative to in vivo models in basic science and pharmaceutical research. In the field of vascular biology, in particular, there has been a lack of a suitable in vitro model exhibiting a three-dimensional structure and the physiological function of vasculature integrated with organ-on-a-chip models. The rapid development of organ-on-a-chip technology is well positioned to fulfill unmet needs. Recently, functional integration of vasculature with diverse microphysiological systems has been increasing. This recent trend corresponds to emerging research interest in how the vascular system contributes to various physiological and pathological conditions. This innovative platform has undergone significant development, but adoption of this technology by end-users and researchers in biology is still a work in progress. Therefore, it is critical to focus on simplification and standardization to promote the distribution and acceptance of this technology by the end-users. In this review, we will introduce the latest developments in vascularized microphysiological systems and summarize their outlook in basic research and drug screening applications.
微生理系统在过去十年中出现，为基础科学和药物研究中的体内模型提供了替代方案。特别是在血管生物学领域，一直缺乏一种合适的体外模型，能够展示具有三维结构和血管生理学功能的器官芯片模型。器官芯片技术的快速发展很好地满足了未满足的需求。最近，血管与各种微生理系统的功能整合正在增加。这一最新趋势反映了人们对血管系统如何影响各种生理和病理状况的研究兴趣日益浓厚。这个创新平台已经取得了重大进展，但生物学领域的最终用户和研究人员对这项技术的采用仍在进行中。因此，专注于简化和标准化以促进最终用户对这项技术的应用和接受至关重要。在这篇综述中，我们将介绍血管化微生理系统的最新进展，并总结它们在基础研究和药物筛选应用中的前景。
