Faculty of Medicine and Health Sciences (Dentistry) University of Barcelona, Bellvitge University Campus Government Pavilion. Office 2-29 C/Feixa Llarga, s/n 08907, L'Hospitalet de Llobregat, Barcelona, Spain
Med Oral Patol Oral Cir Bucal. 2024 Sep 1;29(5):e626-e633. doi: 10.4317/medoral.26603.
Oral lichen planus (OLP) is an inmuno-mediated mucocutaneous chronical inflammatory disease. Multiple predisposing factors are considered, such as autoimmune response, microorganisms, medications, dental materials, psychological stress, genetic predisposition or nutritional deficiencies. The deficiency of vitamin D has been related to various autoimmune diseases like OLP.
The electronic search was conducted in the MEDLINE (Pubmed), Scopus, Cochrane Library and Web of Science databases. To assess any potential risk of bias, the authors critically appraised each study by the Newcastle-Ottawa Scale for cohort and case-control studies. Pooled analyses were performed using a random-effects model. Heterogeneity of the studies was assessed by the I2 statistics. Forest Plots were performed to graphically represent the difference between vitamin D concentrations in the OLP compared to healthy group, with a 95% confidence interval.
After applying our inclusion and exclusion criteria, 7 articles were included in our review. The median concentration vitamin D in ng/ml found in serum for patients with OLP was of 26,6311,75ng/ml and for healthy patients was of 31,438,7ng/ml. Regarding the quantitative analysis, 7 studies were included. The difference in the concentration of vitamin D in healthy patients and patients with OLP statistically significant (Weighted Mean Difference (WMD): -6.20, 95% CI: -11.24 to -1.15, p=0.02 and I2 heterogeneity: 94%, p<0.00001).
The patients with OLP have statistically lower vitamin D levels than healthy patients.
口腔扁平苔藓（OLP）是一种免疫介导的慢性黏膜炎症性疾病。多种诱发因素被认为与该病相关，如自身免疫反应、微生物、药物、牙科材料、心理压力、遗传易感性或营养缺乏等。维生素 D 缺乏与 OLP 等多种自身免疫性疾病有关。
电子检索 MEDLINE（PubMed）、Scopus、Cochrane 图书馆和 Web of Science 数据库。使用 Newcastle-Ottawa 量表对队列和病例对照研究进行批判性评估，以评估任何潜在的偏倚风险。使用随机效应模型进行汇总分析。通过 I2 统计评估研究之间的异质性。使用森林图以图形方式表示 OLP 患者与健康组之间维生素 D 浓度的差异，置信区间为 95%。
应用纳入和排除标准后，有 7 篇文章纳入我们的综述。血清中 OLP 患者的维生素 D 中位数浓度为 26.6311.75ng/ml，健康患者的维生素 D 中位数浓度为 31.438.7ng/ml。关于定量分析，纳入了 7 项研究。健康患者和 OLP 患者之间维生素 D 浓度的差异具有统计学意义（加权均数差（WMD）：-6.20，95%CI：-11.24 至-1.15，p=0.02 和 I2 异质性：94%，p<0.00001）。
与健康患者相比，OLP 患者的维生素 D 水平明显较低。
