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中药干预放射性肺损伤规律的复杂网络分析

[Complex network analysis of law on Chinese herbal drugs intervention on radiation induced lung injury].

作者信息

Tian Jin-Hui, Shi Shu-Zhen, Zhao Ye, Ma Wen-Juan, Liu Rui-Feng, Wang Xiao-Hu, Zhang Jun-Hua

机构信息

Evidence-based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China.

Key Laboratory of Clinical Translational Research and Evidence-based Medicine of Gansu Province, Lanzhou 730000, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2018 Jul;43(14):3018-3025. doi: 10.19540/j.cnki.cjcmm.20180419.001.

Abstract

To mainly analyze the prescription rules of Chinese herbal drugs for radiation induced lung injury, optimize the prescriptions, and provide a reference for the clinical treatment of radiation induced lung injury. The major Chinese databases CNKI, CBM and Wanfang data were searched to obtain the literature on Chinese herbal drugs for radiation induced lung injury. BICOMS 2 software was used to extract and collect all Chinese herbal drugs information and generate the co-occurrence matrix; NetDraw and Gcluto software were then used to make network map and visualization matrix for analysis. A total of 552 articles (19 types and 304 Chinese herbal drugs) were included. Ophiopogon japonicus had the highest frequency (229 times), followed by Astragalus membranaceus(181 times), Glycyrrhiza uralensis (166 times), and Scutellaria baicalensis (150 times). After the classification of efficacy, deficiency-supplementing medicinal (69 kinds of Chinese herbs), heat-clearing medicine (51 kinds of Chinese herbs) and phlegm cough medicine (42 kinds of Chinese herbs) accounted for 53.29% of all the Chinese herbs, acting in the main position. After the prescription analysis for the top 25 herbal prescriptions, six main structures of common prescriptions were found for the treatment of radiation induced lung injury. There are many kinds of Chinese herbal drugs for the treatment of radiation induced lung injury in clinical application. In the future, researchers can mainly focus on Ophiopogon japonicus etc. as the main drugs, combine with other high-frequency Chinese herbal drugs found in this study, or directly refer to the main structures of commonly used prescriptions found in this analysis.

摘要

主要分析放射性肺损伤的中药用药规律,优化方剂,为放射性肺损伤的临床治疗提供参考。检索中国主要数据库知网、中国生物医学文献数据库和万方数据,获取放射性肺损伤的中药文献。运用BICOMS 2软件提取并收集所有中药信息,生成共现矩阵;再使用NetDraw和Gcluto软件制作网络图和可视化矩阵进行分析。共纳入552篇文献(19类,304味中药)。麦冬出现频次最高(229次),其次是黄芪(181次)、甘草(166次)、黄芩(150次)。功效分类后,补虚药(69味中药)、清热药(51味中药)、化痰止咳药(42味中药)占全部中药的53.29%,处于主要地位。对前25首中药方剂进行方剂分析后,发现治疗放射性肺损伤的常用方剂有6种主要结构。临床应用中治疗放射性肺损伤的中药种类较多。未来,研究者可主要关注以麦冬等为主药,结合本研究发现的其他高频中药,或直接参考本分析中常用方剂的主要结构。

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