National Center for Global Health, Istituto Superiore di Sanità, Rome, Italy.
Mult Scler. 2018 Oct;24(12):1526-1535. doi: 10.1177/1352458518792433. Epub 2018 Aug 16.
The vitamin D-binding protein (DBP) occupies a key node in the regulation of the vitamin D system. Being the main plasma carrier of vitamin D metabolites, it regulates their stability and bioavailability. However, DBP is also a multifunctional protein with roles in the organism's actin scavenging system and immunomodulation. All these activities may affect multiple sclerosis (MS) pathophysiology. DBP can be measured in blood and cerebrospinal fluid, body fluids that have been investigated as sources of accessible biomarkers of MS. Yet, available data on DBP expression and function in MS are scattered and somewhat controversial. Aims of this review are to summarize current evidence from studies on DBP in MS patients, to discuss possible shortcomings and to highlight key points that need to be addressed to gain deeper insight into the role of DBP in MS.
维生素 D 结合蛋白 (DBP) 在维生素 D 系统的调节中占据关键节点。作为维生素 D 代谢物的主要血浆载体，它调节其稳定性和生物利用度。然而，DBP 也是一种多功能蛋白，在机体的肌动蛋白清除系统和免疫调节中发挥作用。所有这些活动都可能影响多发性硬化症 (MS) 的病理生理学。DBP 可以在血液和脑脊液中测量，这些体液已被作为 MS 可及生物标志物的来源进行研究。然而，关于 MS 患者 DBP 表达和功能的现有数据分散且存在一些争议。本综述的目的是总结 MS 患者 DBP 研究的现有证据，讨论可能存在的缺陷，并强调需要解决的关键点，以更深入地了解 DBP 在 MS 中的作用。
