Nascimento Carla Manuela Crispim, Pereira Jessica Rodrigues, de Andrade Larissa Pires, Garuffi Marcelo, Talib Leda Leme, Forlenza Orestes Vicente, Cancela Jose Maria, Cominetti Marcia Regina, Stella Florindo
Laboratorio de Biologia do Envelhecimento (LABEN), Departamento de Gerontologia - UFSCar, Rod. Washington Luis, km 235, Sao Carlos - SP, Brazil.
Curr Alzheimer Res. 2014;11(8):799-805. doi: 10.2174/156720501108140910122849.
The benefits of physical exercise to reduce low-grade inflammation and improve Brain-Derived Neurotrophic Factor (BDNF) levels and cognitive function became a growing field of interest. Low-grade inflammation is common during aging and seems to be linked to neurodegenerative process. Regular physical exercises can help to reduce pro-inflammatory cytokines levels and to improve BDNF peripheral concentrations. The main goal of this research was to analyze the effects of a 16-week multimodal physical exercise program on peripheral BDNF levels and on Tumor Necrosis-α (TNF-α) and Interleukin- 6 (IL-6) as pro-inflammatory markers in cognitive healthy elderly individuals and in elderly with mild cognitive impairment (MCI). Cognitive functions were assessed by the Montreal Cognitive Assessment (MoCA) prior to and after the intervention. Thirty cognitively healthy participants and thirty-seven MCI participants were assigned to the control (CG) and trained (TG) groups. The TG participated in a multimodal physical training program for a 16-week period. The results showed a significant between-subjects interaction, which indicates the beneficial contribution of training on the reduction of TNF-α (p=0.001) and IL-6 (p<0.001) and on the improvement of BDNF (p<0.001) peripheral concentrations. Cognitive functions also presented significant improvements for MCI trained group (p=0.03). In conclusion, physical exercise was effective to reduce pro-inflammatory cytokines and to improve BDNF peripheral levels, with positive reflexes on cognition. To the best of our knowledge, this is the first study that evaluated longitudinally the effects of a multimodal physical exercises protocol on peripheral concentrations of pro-inflammatory cytokines and cognition performance in elderly MCI individuals.
体育锻炼对于减轻低度炎症、提高脑源性神经营养因子（BDNF）水平及改善认知功能的益处，已成为一个日益受到关注的领域。低度炎症在衰老过程中很常见，且似乎与神经退行性过程有关。定期体育锻炼有助于降低促炎细胞因子水平，并提高BDNF外周浓度。本研究的主要目的是分析一项为期16周的多模式体育锻炼计划，对认知健康的老年人以及轻度认知障碍（MCI）老年人外周BDNF水平、肿瘤坏死因子-α（TNF-α）和白细胞介素-6（IL-6）作为促炎标志物的影响。在干预前后，通过蒙特利尔认知评估（MoCA）对认知功能进行评估。30名认知健康参与者和37名MCI参与者被分配到对照组（CG）和训练组（TG）。TG组参加了为期16周的多模式体育训练计划。结果显示，组间存在显著交互作用，这表明训练对降低TNF-α（p=0.001）和IL-6（p<0.001）以及提高BDNF外周浓度（p<0.001）具有有益作用。MCI训练组的认知功能也有显著改善（p=0.03）。总之，体育锻炼能有效降低促炎细胞因子水平并提高BDNF外周水平，对认知有积极影响。据我们所知，这是第一项纵向评估多模式体育锻炼方案对老年MCI个体促炎细胞因子外周浓度和认知表现影响的研究。
