Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, 05508000 Sao Paulo-SP, Brazil.
Exercise and Immunometabolism Research Group, Department of Physical Education, Universidade Estadual Paulista (UNESP), 19060-900 Presidente Prudente-SP, Brazil.
Mediators Inflamm. 2018 Jul 4;2018:8261432. doi: 10.1155/2018/8261432. eCollection 2018.
Visceral obesity is frequently associated with the development of type 2 diabetes (T2D), a highly prevalent chronic disease that features insulin resistance and pancreatic -cell dysfunction as important hallmarks. Recent evidence indicates that the chronic, low-grade inflammation commonly associated with visceral obesity plays a major role connecting the excessive visceral fat deposition with the development of insulin resistance and pancreatic -cell dysfunction. Herein, we review the mechanisms by which nutrients modulate obesity-associated inflammation.
内脏型肥胖常与 2 型糖尿病（T2D）的发生相关，后者是一种高发的慢性疾病，其特征为胰岛素抵抗和胰岛细胞功能障碍。近期证据表明，与内脏型肥胖相关的慢性、低度炎症在将过多的内脏脂肪沉积与胰岛素抵抗和胰岛细胞功能障碍的发生联系起来方面发挥着重要作用。在此，我们综述了营养素调节肥胖相关炎症的机制。
