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一种新型高性能钆纳米管-聚合物杂化材料，可用于通过 MRI 对干细胞进行标记和示踪。

A New High-Performance Gadonanotube-Polymer Hybrid Material for Stem Cell Labeling and Tracking by MRI.

机构信息

Department of Chemistry, The Smalley-Curl Institute, Rice University, M.S. 60, P.O. Box 1892, Houston, TX 77251-1892, USA.

Stem Cell Center, Texas Heart Institute, Baylor St. Luke's Medical Center, MC 2-255, P.O. Box 20345, Houston, TX 77225-0345, USA.

出版信息

Contrast Media Mol Imaging. 2018 Jul 10;2018:2853736. doi: 10.1155/2018/2853736. eCollection 2018.

DOI:10.1155/2018/2853736
PMID:30116161
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6079544/
Abstract

A gentle, rapid method has been developed to introduce a polyacrylic acid (PAA) polymer coating on the surface of gadonanotubes (GNTs) which significantly increases their dispersibility in water without the need of a surfactant. As a result, the polymer, with its many carboxylic acid groups, coats the surface of the GNTs to form a new GNT-polymer hybrid material (PAA-GNT) which can be highly dispersed in water (ca. 20 mg·mL) at physiological pH. When dispersed in water, the new PAA-GNT material is a powerful MRI contrast agent with an extremely short water proton spin-lattice relaxation time () which results in a -weighted relaxivity of 150 mM·s per Gd ion at 1.5 T. Furthermore, the PAA-GNTs have been used to safely label porcine bone-marrow-derived mesenchymal stem cells for magnetic resonance imaging. The labeled cells display excellent image contrast in phantom imaging experiments, and transmission electron microscopy images of the labeled cells reveal the presence of highly dispersed PAA-GNTs within the cytoplasm with 10 Gd ions per cell.

摘要

一种温和、快速的方法被开发出来，在镧系纳米管（GNTs）的表面引入聚丙烯酸（PAA）聚合物涂层，这显著增加了它们在水中的分散性，而不需要表面活性剂。结果，聚合物的许多羧酸基团覆盖在 GNTs 的表面，形成一种新的 GNT-聚合物杂化材料（PAA-GNT），可以在生理 pH 值下高度分散在水中（约 20mg·mL）。当分散在水中时，这种新的 PAA-GNT 材料是一种强大的 MRI 对比剂，具有极短的水质子自旋晶格弛豫时间（T1），导致在 1.5T 时每个 Gd 离子的重量弛豫率为 150mM·s。此外，PAA-GNTs 已被用于安全标记猪骨髓间充质干细胞的磁共振成像。在幻影成像实验中，标记的细胞显示出极好的图像对比，并且标记细胞的透射电子显微镜图像显示，在细胞质内存在高度分散的 PAA-GNTs，每个细胞内有 10 个 Gd 离子。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6388/6079544/dfce758d2394/CMMI2018-2853736.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6388/6079544/6252af4456cc/CMMI2018-2853736.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6388/6079544/b8725e9a8574/CMMI2018-2853736.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6388/6079544/28fa2040eb9e/CMMI2018-2853736.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6388/6079544/3a6260829c30/CMMI2018-2853736.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6388/6079544/82d68b65c9ee/CMMI2018-2853736.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6388/6079544/dfce758d2394/CMMI2018-2853736.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6388/6079544/6252af4456cc/CMMI2018-2853736.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6388/6079544/b8725e9a8574/CMMI2018-2853736.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6388/6079544/28fa2040eb9e/CMMI2018-2853736.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6388/6079544/3a6260829c30/CMMI2018-2853736.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6388/6079544/82d68b65c9ee/CMMI2018-2853736.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6388/6079544/dfce758d2394/CMMI2018-2853736.006.jpg

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