He Yang, Hu Chenyan, Li Zhijia, Wu Chuan, Zeng Yuanyuan, Peng Cheng
State Key Laboratory of Southwestern Chinese Medicine Resources, College of Medical Technology, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 611137, China.
Mater Today Bio. 2022 Mar;14:100231. doi: 10.1016/j.mtbio.2022.100231. Epub 2022 Mar 5.
Infectious diseases (such as Corona Virus Disease 2019) and tumors pose a tremendous challenge to global public health. Early diagnosis of infectious diseases and tumors can lead to effective control and early intervention of the patient's condition. Over the past few decades, carbon nanomaterials (CNs) have attracted widespread attention in different scientific disciplines. In the field of biomedicine, carbon nanotubes, graphene, carbon quantum dots and fullerenes have the ability of improving the accuracy of the diagnosis by the improvement of the diagnostic approaches. Therefore, this review highlights their applications in the diagnosis of infectious diseases and tumors over the past five years. Recent advances in the field of biosensing, bioimaging, and nucleic acid amplification by such CNs are introduced and discussed, emphasizing the importance of their unique properties in infectious disease and tumor diagnosis and the challenges and opportunities that exist for future clinical applications. Although the application of CNs in the diagnosis of several diseases is still at a beginning stage, biosensors, bioimaging technologies and nucleic acid amplification technologies built on CNs represent a new generation of promising diagnostic tools that further support their potential application in infectious disease and tumor diagnosis.
传染病（如2019冠状病毒病）和肿瘤对全球公共卫生构成了巨大挑战。传染病和肿瘤的早期诊断能够实现对患者病情的有效控制和早期干预。在过去几十年中，碳纳米材料在不同科学领域引起了广泛关注。在生物医学领域，碳纳米管、石墨烯、碳量子点和富勒烯通过改进诊断方法，具备提高诊断准确性的能力。因此，本综述重点介绍了它们在过去五年中在传染病和肿瘤诊断中的应用。介绍并讨论了此类碳纳米材料在生物传感、生物成像和核酸扩增领域的最新进展，强调了它们独特性质在传染病和肿瘤诊断中的重要性以及未来临床应用所面临的挑战和机遇。尽管碳纳米材料在几种疾病诊断中的应用仍处于起步阶段，但基于碳纳米材料构建的生物传感器、生物成像技术和核酸扩增技术代表了新一代有前景的诊断工具，进一步支持了它们在传染病和肿瘤诊断中的潜在应用。
