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1-（4-苯氧基苄基）5-氨基尿嘧啶衍生物及其类似物——新型人腺病毒复制抑制剂

1-(4-Phenoxybenzyl) 5-Aminouracil Derivatives and Their Analogues - Novel Inhibitors of Human Adenovirus Replication.

作者信息

Nikitenko N A, Gureeva E S, Ozerov A A, Tukhvatulin A I, Izhaeva F M, Prassolov V S, Deryabin P G, Novikov M S, Logunov D Y

机构信息

N.F. Gamaleya Federal National Research Center for Epidemiology and Microbiology, Gamaleya Str. 18, Moscow, 123098, Russia.

Volgograd State Medical University, Pavshih Bortsov Sq. 1,Volgograd, 400131, Russia.

出版信息

Acta Naturae. 2018 Apr-Jun;10(2):58-64.

PMID:30116616
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6087815/
Abstract

Adenovirus infections are characterized by widespread distribution. The lack of causal therapy, which is effective in treating this group of diseases, explains the need for new therapeutic drugs. Notably, anti-adenoviral activity of [4-(phenoxy)benzyl]-5-(phenylamino)-6-azauracil, 1-[4-(phenoxy)benzyl]-5-(morpholino) uracil, 1-[4-(4-chlorophenoxy)benzyl]-5-(morpholino) uracil, and 1-[4-(4-fluorophenoxy)-benzyl]-5-(morpholino) uracil was observed.

摘要

腺病毒感染的特点是分布广泛。由于缺乏对这类疾病有效的病因治疗方法，因此需要新的治疗药物。值得注意的是，观察到了[4-(苯氧基)苄基]-5-(苯氨基)-6-氮杂尿嘧啶、1-[4-(苯氧基)苄基]-5-(吗啉代)尿嘧啶、1-[4-(4-氯苯氧基)苄基]-5-(吗啉代)尿嘧啶和1-[4-(4-氟苯氧基)苄基]-5-(吗啉代)尿嘧啶的抗腺病毒活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c258/6087815/f7491f66d00c/AN20758251-10-02-058-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c258/6087815/7de5bdc30663/AN20758251-10-02-058-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c258/6087815/d760d9242100/AN20758251-10-02-058-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c258/6087815/b8ff9be3ae1c/AN20758251-10-02-058-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c258/6087815/c92f573e46cf/AN20758251-10-02-058-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c258/6087815/f7491f66d00c/AN20758251-10-02-058-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c258/6087815/7de5bdc30663/AN20758251-10-02-058-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c258/6087815/d760d9242100/AN20758251-10-02-058-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c258/6087815/b8ff9be3ae1c/AN20758251-10-02-058-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c258/6087815/c92f573e46cf/AN20758251-10-02-058-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c258/6087815/f7491f66d00c/AN20758251-10-02-058-g005.jpg

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本文引用的文献

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Regulation of Human Adenovirus Replication by RNA Interference.RNA干扰对人腺病毒复制的调控
Acta Naturae. 2015 Jul-Sep;7(3):100-7.
2
Targeting species D adenoviruses replication to counteract the epidemic keratoconjunctivitis.
Biochimie. 2015 Jun;113:10-6. doi: 10.1016/j.biochi.2015.03.010. Epub 2015 Mar 19.
3
Human adenovirus: Viral pathogen with increasing importance.人腺病毒：一种重要性日益增加的病毒病原体。
Eur J Microbiol Immunol (Bp). 2014 Mar;4(1):26-33. doi: 10.1556/EuJMI.4.2014.1.2. Epub 2014 Mar 14.
4
Synthesis and anti-HCMV activity of 1-[ω-(phenoxy)alkyl]uracil derivatives and analogues thereof.1-[ω-(苯氧基)烷基]尿嘧啶衍生物及其类似物的合成及抗 HCMV 活性。
Bioorg Med Chem. 2013 Jul 15;21(14):4151-7. doi: 10.1016/j.bmc.2013.05.009. Epub 2013 May 16.
5
Adenoviral keratoconjunctivitis: an update.腺病毒性角结膜炎：最新进展
Arch Soc Esp Oftalmol. 2013 Mar;88(3):108-15. doi: 10.1016/j.oftal.2012.07.007. Epub 2012 Sep 25.
6
Adenovirus in solid organ transplantation.实体器官移植中的腺病毒
Am J Transplant. 2013 Mar;13 Suppl 4:206-11. doi: 10.1111/ajt.12112.
7
Quantitative real-time PCR assay panel for detection and type-specific identification of epidemic respiratory human adenoviruses.用于检测和特定型别鉴定流行呼吸道人类腺病毒的定量实时 PCR 检测试剂盒。
J Clin Microbiol. 2013 Apr;51(4):1089-93. doi: 10.1128/JCM.03297-12. Epub 2013 Jan 16.
8
Adenovirus.腺病毒。
Semin Respir Crit Care Med. 2011 Aug;32(4):494-511. doi: 10.1055/s-0031-1283287. Epub 2011 Aug 19.
9
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10
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Infect Genet Evol. 2011 Aug;11(6):1208-17. doi: 10.1016/j.meegid.2011.04.031. Epub 2011 May 5.