Cardiology Research Institute, 111a Kievskaya Street, Tomsk 634012, Russia.
J Diabetes Res. 2018 Jul 10;2018:1780683. doi: 10.1155/2018/1780683. eCollection 2018.
The objective of the study was to assess the impact of DM2 at baseline on long-term mortality after acute myocardial infarction (MI) among different age groups. The data were taken from: "Register of Acute Myocardial Infarction." A total of 862 patients were followed for five years after acute myocardial infarction. The primary endpoint was death from any cause. The patients were categorized into 2 groups based on their ages: group 1-comprised patients older than working age ( = 358) and group 2-comprised employable patients ( = 504). A total of 208 patients were diagnosed with both cardiovascular disease and DM2. Elderly patients with DM2 had worse prognosis and increased five-year mortality compared with patients of the same age group without DM2. Statistically significant differences in long-term outcomes were found in adult patients ( = 0.004) only in group with longer duration of diabetes, unlike the group with DM2 onset. In conclusion, Type 2 DM increased 5-year mortality rate of elderly patients with myocardial infarction. However, younger patients with both myocardial infarction and DM2 had more complications in the early post-MI period compared with patients of the same age group without DM2 but did not show any statistically significant differences in the long-term outcome.
本研究旨在评估基线时 2 型糖尿病(DM2)对不同年龄组急性心肌梗死(MI)后长期死亡率的影响。数据取自:“急性心肌梗死登记处”。共有 862 例患者在急性心肌梗死后随访 5 年。主要终点为任何原因导致的死亡。根据年龄将患者分为 2 组:第 1 组为年龄大于工作年龄(=358)的患者,第 2 组为可就业患者(=504)。共有 208 例患者同时患有心血管疾病和 DM2。与同年龄组无 DM2 的患者相比,患有 DM2 的老年患者预后较差,五年死亡率更高。仅在糖尿病病程较长的成年患者(=0.004)中发现长期预后存在统计学显著差异,而在 DM2 发病组中则没有。总之,2 型糖尿病增加了老年心肌梗死患者的 5 年死亡率。然而,与同年龄组无 DM2 的患者相比,同时患有心肌梗死和 DM2 的年轻患者在 MI 后早期有更多并发症,但在长期预后方面没有统计学显著差异。