Department of Pediatrics, University Hospital Hradec Kralove, Faculty of Medicine in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic.
Philosophy Faculty, Palacky University Olomouc, Olomouc, Czech Republic.
J Diabetes Res. 2018 Jul 8;2018:8105407. doi: 10.1155/2018/8105407. eCollection 2018.
The poor metabolic control in type 1 diabetes mellitus (T1D) has a negative impact on the developing brain. Hyperglycemia and glycemic fluctuations disrupt mainly executive functions. To assess a hypothesized deficit of the executive functions, we evaluated visual processing and reaction time in an oddball task.
Oddball visual event-related potentials (ERPs), reaction time, and pattern-reversal visual evoked potentials (VEPs) were examined in a cohort of twenty-two 12- to 18-year-old T1D patients without diabetic retinopathy at normal glycemia and in nineteen 10- to 21-year-old healthy controls.
The P100 peak time of the VEPs was significantly prolonged in T1D patients compared with the control group ( < 0.017). In contrast to the deteriorated sensory response, the area under the curve of the P3b component of the ERPs was significantly larger ( = 0.035) in patients, while reaction time in the same task did not differ between groups ( = 0.713).
The deterioration on a sensory level, enhanced activity during cognitive processing, and balanced behavioral response support the view that neuroplasticity counterbalances the neural impairment by enhanced cognitive processing to achieve normal behavioral performance in T1D adolescents.
1 型糖尿病（T1D）患者的代谢控制不佳对发育中的大脑有负面影响。高血糖和血糖波动主要破坏执行功能。为了评估执行功能的假设缺陷，我们在一项Oddball 任务中评估了视觉处理和反应时间。
我们在血糖正常的 22 名 12 至 18 岁的 T1D 患者和 19 名 10 至 21 岁的健康对照者中检查了 Oddball 视觉事件相关电位（ERP）、反应时间和模式反转视觉诱发电位（VEP）。
与对照组相比，T1D 患者的 VEP 的 P100 峰时间明显延长（<0.017）。与感觉反应恶化相反，ERP 的 P3b 成分的曲线下面积在患者中明显更大（=0.035），而在相同任务中两组的反应时间没有差异（=0.713）。
在感觉水平上的恶化、认知加工过程中的增强活动以及平衡的行为反应支持这样一种观点，即神经可塑性通过增强认知处理来抵消神经损伤，从而使 T1D 青少年获得正常的行为表现。
