Villa L L, Lopes A
Int J Cancer. 1986 Jun 15;37(6):853-5. doi: 10.1002/ijc.2910370610.
To detect the presence of human papillomavirus (HPV) DNA in penile cancers, 18 squamous-cell carcinomas were studied by Southern blot analysis. All specimens were from Brazilian patients ranging in age from 31 to 78 years. Of these, 7 harbored DNA sequence homology. Most positive specimens contained more than 100 copies of viral DNA. No HPV 16 was detected in our samples. Presence of HPV DNA sequences in the samples studied was not correlated with the patients' age or race, nor with extent or progress of disease.
为检测阴茎癌中人类乳头瘤病毒（HPV）DNA的存在情况，采用Southern印迹分析法对18例鳞状细胞癌进行了研究。所有标本均来自年龄在31岁至78岁之间的巴西患者。其中，7例含有DNA序列同源性。大多数阳性标本含有超过100个病毒DNA拷贝。在我们的样本中未检测到HPV 16。所研究样本中HPV DNA序列的存在与患者的年龄、种族无关，也与疾病的范围或进展无关。
