The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen N, Denmark.
Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen N, Denmark.
J Clin Endocrinol Metab. 2021 May 13;106(6):1718-1727. doi: 10.1210/clinem/dgab098.
The importance of fasting glucagon-like peptide-1 (GLP-1) in altered metabolic outcomes has been questioned.
This work aimed to assess whether fasting GLP-1 differs in children and adolescents with overweight/obesity compared to a population-based reference, and whether concentrations predict cardiometabolic risk (CMR) factors.
Analyses were based on The Danish Childhood Obesity Data- and Biobank, a cross-sectional study including children and adolescents, aged 6 to 19 years, from an obesity clinic group (n = 1978) and from a population-based group (n = 2334). Fasting concentrations of plasma total GLP-1 and quantitative CMR factors were assessed. The effects of GLP-1 as a predictor of CMR risk outcomes were examined by multiple linear and logistic regression modeling.
The obesity clinic group had higher fasting GLP-1 concentrations (median 3.3 pmol/L; interquartile range, 2.3-4.3 pmol/L) than the population-based group (2.8 pmol/L; interquartile range, 2.1-3.8 pmol/L; P < 2.2E-16). Body mass index SD score (SDS), waist circumference, and total body fat percentage were significant predictors of fasting GLP-1 concentrations in boys and girls. Fasting GLP-1 concentrations were positively associated with homeostasis model assessment of insulin resistance, fasting values of insulin, high-sensitivity C-reactive protein, C-peptide, triglycerides, alanine transaminase (ALT), glycated hemoglobin A1c, and SDS of diastolic and systolic blood pressure. A 1-SD increase in fasting GLP-1 was associated with an increased risk of insulin resistance (odds ratio [OR] 1.59), dyslipidemia (OR 1.16), increased ALT (OR 1.14), hyperglycemia (OR 1.12) and hypertension (OR 1.12).
Overweight/obesity in children and adolescents is associated with increased fasting plasma total GLP-1 concentrations, which was predictive of higher CMR factors.
空腹胰高血糖素样肽-1（GLP-1）在代谢改变结局中的重要性受到质疑。
本研究旨在评估超重/肥胖儿童和青少年的空腹 GLP-1 是否与基于人群的参考值不同，以及浓度是否可预测心血管代谢风险（CMR）因素。
分析基于丹麦儿童肥胖数据和生物库，这是一项横断面研究，纳入了来自肥胖诊所组（n=1978）和基于人群组（n=2334）的 6-19 岁儿童和青少年。评估了空腹血浆总 GLP-1 浓度和定量 CMR 因素。通过多元线性和逻辑回归模型检查 GLP-1 作为 CMR 风险结果的预测因子的效果。
肥胖诊所组的空腹 GLP-1 浓度（中位数 3.3 pmol/L；四分位距 2.3-4.3 pmol/L）高于基于人群组（2.8 pmol/L；四分位距 2.1-3.8 pmol/L；P<2.2E-16）。男孩和女孩的 BMI SDS、腰围和体脂肪百分比是空腹 GLP-1 浓度的显著预测因子。空腹 GLP-1 浓度与胰岛素抵抗的稳态模型评估、空腹胰岛素、高敏 C 反应蛋白、C 肽、甘油三酯、丙氨酸氨基转移酶（ALT）、糖化血红蛋白 A1c 以及舒张压和收缩压的 SDS 呈正相关。空腹 GLP-1 增加 1-SD 与胰岛素抵抗风险增加（比值比 [OR] 1.59）、血脂异常（OR 1.16）、ALT 升高（OR 1.14）、高血糖（OR 1.12）和高血压（OR 1.12）相关。
超重/肥胖的儿童和青少年与空腹血浆总 GLP-1 浓度增加相关，而浓度可预测更高的 CMR 因素。
