Trendafilova Antoaneta, Moujir Laila M, Sousa Pedro M C, Seca Ana M L
Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., bl. 9, 1113 Sofia, Bulgaria.
Department of Biochemistry, Microbiology, Genetics and Cell Biology, Facultad de Farmacia, Universidad de La Laguna, 38206 La Laguna, Tenerife, Spain.
Foods. 2020 Dec 30;10(1):65. doi: 10.3390/foods10010065.
The genus , often known collectively as "wormwood", has aroused great interest in the scientific community, pharmaceutical and food industries, generating many studies on the most varied aspects of these plants. In this review, the most recent evidence on health effects of edible species and some of its constituents are presented and discussed, based on studies published until 2020, available in the Scopus, Web of Sciences and PubMed databases, related to food applications, nutritional and sesquiterpene lactones composition, and their therapeutic effects supported by in vivo and clinical studies. The analysis of more than 300 selected articles highlights the beneficial effect on health and the high clinical relevance of several species besides some sesquiterpene lactones constituents and their derivatives. From an integrated perspective, as it includes therapeutic and nutritional properties, without ignoring some adverse effects described in the literature, this review shows the great potential of plants and some of their constituents as dietary supplements, functional foods and as the source of new, more efficient, and safe medicines. Despite all the benefits demonstrated, some gaps need to be filled, mainly related to the use of raw extracts, such as its standardization and clinical trials on adverse effects and its health care efficacy.
该属植物通常被统称为“艾草”，在科学界、制药和食品行业引起了极大的兴趣，引发了许多关于这些植物各个方面的研究。在本综述中，基于截至2020年发表在Scopus、科学网和PubMed数据库中的研究，介绍并讨论了可食用艾草种类及其一些成分对健康影响的最新证据，这些研究涉及食品应用、营养成分和倍半萜内酯成分，以及体内和临床研究支持的治疗效果。对300多篇精选文章的分析突出了除一些倍半萜内酯成分及其衍生物外，几种艾草种类对健康的有益影响以及较高的临床相关性。从综合角度来看，由于它兼具治疗和营养特性，同时也不忽视文献中描述的一些不良反应，本综述表明艾草植物及其一些成分作为膳食补充剂、功能性食品以及新型、更高效和安全药物来源具有巨大潜力。尽管已证明有诸多益处，但仍存在一些需要填补的空白，主要涉及生艾草提取物的使用，如标准化以及关于不良反应和医疗保健功效的临床试验。
