Department of Ophthalmology, New Zealand National Eye Centre, The University of Auckland, New Zealand.
Department of Ophthalmology, New Zealand National Eye Centre, The University of Auckland, New Zealand.
Cont Lens Anterior Eye. 2018 Dec;41(6):513-517. doi: 10.1016/j.clae.2018.08.003. Epub 2018 Aug 14.
To compare the in vitro anti-demodectic activity of four commercially available dedicated eyelid cleansers (Cliradex towelette cleanser, Oust™ Demodex cleanser, Blephadex™ eyelid foam, TheraTears SteriLid eyelid cleanser), tea tree oil, undiluted terpinen-4-ol and linalool; and to assess the terpinen-4-ol content of the commercial cleansers and tea tree oil.
In vitro anti-demodectic efficacy assessment: 93 viable Demodex mites were acquired from the epilated eyelashes of 10 participants, and were randomised to application with one of the four eyelid cleansers, 100% and 50% tea tree oil, undiluted terpinen-4-ol and linalool, or no treatment. Following treatment application, mite viability was assessed for 300 min, based on limb/body movement and/or the development of a crenated/translucent appearance. Kaplan-Meier survival analysis was then performed.
The absolute concentration of terpinen-4-ol and the relative abundance of linalool in the four eyelid cleansers and tea tree oil were determined.
In vitro anti-demodectic efficacy assessment: No significant differences were observed between undiluted tea tree oil, terpinen-4-ol and linalool (all p > 0.05). Although all commercial eyelid cleansers effected lower mite survival probabilities than the untreated group, Cliradex was the only eyelid cleanser that demonstrated comparable antiparastic activity to 50% tea tree oil (p = 0.36).
Among the four eyelid cleansers, Cliradex contained the highest concentration of terpinen-4-ol, while linalool was present in TheraTears SteriLid only.
Of the four commercial eyelid cleansers, Cliradex demonstrated the highest levels of in vitro anti-demodectic activity and terpinen-4-ol content. Undiluted linalool and terpenin-4-ol showed comparable antiparasitic efficacy, and the use of linalool in the management of demodectic blepharitis warrants further investigation.
比较四种市售专用眼睑清洁剂（Cliradex 拭子清洁剂、Oust™ Demodex 清洁剂、Blephadex™ 眼睑泡沫、TheraTears SteriLid 眼睑清洁剂）、茶树油、未稀释的萜品-4-醇和芳樟醇的体外抗蠕形螨活性；并评估商业清洁剂和茶树油中的萜品-4-醇含量。
体外抗蠕形螨功效评估：从 10 名参与者的脱毛睫毛中获得 93 只存活的蠕形螨，将其随机分配至应用四种眼睑清洁剂之一、100%和 50%的茶树油、未稀释的萜品-4-醇和芳樟醇或不治疗。治疗后，根据肢体/身体运动和/或出现嵴状/半透明外观，评估螨虫的存活情况 300 分钟。然后进行 Kaplan-Meier 生存分析。
确定四种眼睑清洁剂和茶树油中萜品-4-醇的绝对浓度和芳樟醇的相对丰度。
体外抗蠕形螨功效评估：未稀释的茶树油、萜品-4-醇和芳樟醇之间未见显著差异（均 P>0.05）。尽管所有市售眼睑清洁剂对螨虫的存活概率的影响均低于未治疗组，但只有 Cliradex 清洁剂显示出与 50%茶树油相当的驱虫活性（P=0.36）。
在四种眼睑清洁剂中，Cliradex 清洁剂含有最高浓度的萜品-4-醇，而芳樟醇仅存在于 TheraTears SteriLid 清洁剂中。
在四种市售眼睑清洁剂中，Cliradex 清洁剂表现出最高水平的体外抗蠕形螨活性和萜品-4-醇含量。未稀释的芳樟醇和萜品-4-醇表现出相当的驱虫效果，芳樟醇在蠕形螨性睑缘炎治疗中的应用值得进一步研究。
