Ophthalmology Private Practice, Nuremberg, Germany.
Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen-Nuremberg, Germany.
Curr Eye Res. 2022 Mar;47(3):352-360. doi: 10.1080/02713683.2021.1978099. Epub 2021 Sep 26.
PURPOSE/AIM OF THE STUDY: To evaluate the improvement of ocular signs and symptoms in patients suffering from Demodex blepharitis using a combined treatment approach: use of eyelid wipes impregnated with 2.5% terpinen-4-ol (T4O) and 0.2% hyaluronic acid (HA) in the initial treatment period and investigation of maintenance of the treatment effect with the use of eyelid cleansing wipes.
Fifty patients with Demodex blepharitis were treated in the initial treatment period with sterile eyelid T4O impregnated wipes for 28 days. In the following four-week maintenance period, 82% patients received sterile eyelid maintenance wipes, while 16% continued treatment with T4O impregnated wipes. Global ocular discomfort, adapted TOSS, SANDE score, and individual blepharitis symptoms were assessed by patients at day 28 and day 56. Ocular signs were evaluated by the investigator at the study visits. Investigator's assessment of the overall treatment performance, patient's assessment of treatment satisfaction, and tolerability were evaluated with questionnaires.
All global ocular discomfort symptoms and disease specific symptoms assessed by patients as well as all parameters evaluated by the investigators significantly improved in the initial treatment period with the application of eyelid wipes impregnated with 2.5% terpinen-4-ol until day 28. The therapeutic effect was maintained or even improved during the maintenance period under administration of mainly eyelid maintenance wipes until day 56. Both products were well tolerated. No adverse events and no clinically relevant changes in visual acuity were observed during both periods.
Once daily treatment with T4O impregnated eyelid wipes in the initial treatment period significantly improved the ocular symptoms and signs and reduced the mite count in patients with Demodex blepharitis within four-weeks administration. Subsequent maintenance treatment with maintenance wipes for another 4 weeks preserved or further intensified the treatment success. The products were well tolerated and were convenient to use.
评估使用 2.5%萜品烯-4-醇（T4O）和 0.2%透明质酸（HA）浸渍的眼睑擦拭物联合治疗方法对患有螨虫性睑缘炎的患者的眼部症状和体征的改善情况，并通过使用眼睑清洁擦拭物来研究治疗效果的维持情况。
在初始治疗期间，50 名螨虫性睑缘炎患者使用无菌 T4O 浸渍眼睑擦拭物治疗 28 天。在接下来的四周维持期内，82%的患者接受无菌眼睑维持擦拭物治疗，而 16%的患者继续使用 T4O 浸渍擦拭物治疗。患者在第 28 天和第 56 天评估整体眼部不适、改良的 TOSS、SANDE 评分和个体睑缘炎症状。研究者在研究访视时评估眼部体征。通过问卷评估研究者对整体治疗效果的评估、患者对治疗满意度的评估以及治疗的耐受性。
在初始治疗期间，使用 2.5%萜品烯-4-醇浸渍的眼睑擦拭物，患者评估的所有整体眼部不适症状和疾病特异性症状以及研究者评估的所有参数均在第 28 天显著改善。在主要使用眼睑维持擦拭物的维持期内，治疗效果得到维持或甚至在第 56 天进一步改善。两种产品均具有良好的耐受性。在两个时期均未观察到不良反应和视力的临床相关变化。
在初始治疗期间，每日一次使用 T4O 浸渍的眼睑擦拭物治疗可显著改善螨虫性睑缘炎患者的眼部症状和体征，并在四周的治疗期间减少螨虫数量。随后在接下来的四周内使用维持擦拭物进行维持治疗可保持或进一步强化治疗效果。这些产品具有良好的耐受性，且使用方便。
