Department of Ophthalmology (Schrecker), Rudolf Virchow Klinikum Glauchau, Glauchau, the Institute of Experimental Ophthalmology (Langenbucher, Eppig) and the Department of Ophthalmology (Seitz), Saarland University, Homburg/Saar, Germany.
Department of Ophthalmology (Schrecker), Rudolf Virchow Klinikum Glauchau, Glauchau, the Institute of Experimental Ophthalmology (Langenbucher, Eppig) and the Department of Ophthalmology (Seitz), Saarland University, Homburg/Saar, Germany.
J Cataract Refract Surg. 2018 Oct;44(10):1211-1219. doi: 10.1016/j.jcrs.2018.06.055. Epub 2018 Aug 14.
To assess the feasibility of individual compensation of corneal spherical aberration with a custom intraocular lens (IOL).
Department of Ophthalmology, Rudolf Virchow Klinikum Glauchau, Glauchau, Germany.
Prospective case series.
Cataract patients were randomized to receive an individual aberration-correcting IOL (Invidua-aA; Group A) or a standard aspheric aberration-free IOL of otherwise identical design (Aspira-aA; Group B). In Group A, the IOL was designed according to preoperative calculation of the corneal spherical aberration Z(4,0). The aim was to achieve an overall postoperative ocular spherical aberration close to zero. Four weeks and 3 months postoperatively, the refraction, visual acuity (far, intermediate, and near distance), photopic and mesopic contrast sensitivities (with and without glare), defocus curve, corneal and ocular spherical aberration, and pupil size were measured.
Group A, 57 eyes of 42 patients and Group B, 29 eyes of 27 patients. Preoperatively, there was no difference in corneal spherical aberration between groups (P > .05). Three months postoperatively, residual ocular spherical aberration Z(4,0) was significantly lower in Group A (P < .001). Photopic and mesopic contrast sensitivities (with and without glare) were significantly higher in Group A at most spatial frequencies. Monocular defocus curve and distance, intermediate, and near visual acuity outcomes did not differ significantly between groups.
Implantation of a custom monofocal aspheric IOL effectively reduced overall ocular spherical aberration. Clinical outcomes indicate that IOLs with an individual spherical aberration correction improve functional vision, especially contrast sensitivity, compared with standard aberration-free IOLs.
评估通过定制人工晶状体（IOL）对角膜球差进行个体补偿的可行性。
德国格劳豪的鲁道夫·维乔克克林金姆眼科。
前瞻性病例系列。
白内障患者被随机分为接受个体化像差矫正 IOL（Invidua-aA；A 组）或具有相同设计的标准非球面前像差自由 IOL（Aspira-aA；B 组）。在 A 组中，IOL 根据术前计算的角膜球差 Z(4,0)进行设计。目的是使术后总体眼球差接近零。术后 4 周和 3 个月，测量屈光度、远、中、近视力（远距离、中间距离和近距离）、明视觉和中间视觉对比敏感度（有眩光和无眩光）、离焦曲线、角膜和眼球差以及瞳孔大小。
A 组 42 例 57 眼，B 组 27 例 29 眼。术前两组角膜球差无差异（P>.05）。术后 3 个月，A 组残余眼球差 Z(4,0)明显降低（P<.001）。在大多数空间频率下，A 组明视觉和中间视觉对比敏感度（有眩光和无眩光）均显著提高。单眼离焦曲线和远、中、近视力无明显差异。
植入定制的单焦点非球面 IOL 可有效降低总眼球差。临床结果表明，与标准无像差 IOL 相比，具有个体球差矫正的 IOL 可改善功能视力，特别是对比敏感度。
