Beaudenon S, Kremsdorf D, Croissant O, Jablonska S, Wain-Hobson S, Orth G
Nature. 1986;321(6067):246-9. doi: 10.1038/321246a0.
The role of human papillomaviruses (HPVs) in the development of genital neoplasias has been well documented. The genomes of two HPV types, HPV16 and HPV18, have been found to be associated with about 70% of invasive carcinomas of the uterine cervix. As, under non-stringent hybridization conditions, HPV DNA sequences have been detected in about 90% of cervical carcinomas, it seems likely that additional HPV types are associated with these tumours. Here we report the molecular cloning and characterization of a novel HPV type, tentatively named HPV33, whose sequences have been detected in 4-8% of biopsies of genital intra-epithelial neoplasias and cervical invasive carcinomas, usually as free monomeric or oligomeric molecules. However, in one specimen of vulvar Bowen's disease, HPV33 DNA sequences were integrated in the host-cell genome. Thus, HPV33 probably represents an additional type of potentially oncogenic genital HPV.
人乳头瘤病毒（HPV）在生殖器肿瘤发生过程中的作用已有充分文献记载。已发现两种HPV类型，即HPV16和HPV18，其基因组与约70%的子宫颈浸润癌有关。由于在非严格杂交条件下，约90%的宫颈癌中检测到HPV DNA序列，因此似乎还有其他HPV类型与这些肿瘤有关。在此，我们报告一种新型HPV类型的分子克隆和特性，暂定名为HPV33，其序列在4%-8%的生殖器上皮内瘤变和宫颈浸润癌活检组织中检测到，通常为游离的单体或寡聚体分子。然而，在一份外阴鲍温病标本中，HPV33 DNA序列整合到宿主细胞基因组中。因此，HPV33可能代表另一种潜在致癌的生殖器HPV类型。
