Blackwell Simon E, Westermann Katharina, Woud Marcella L, Cwik Jan C, Neher Torsten, Graz Christian, Nyhuis Peter W, Margraf Jürgen
1Mental Health Research and Treatment Center, Faculty of Psychology, Ruhr-Universität Bochum, Massenbergstraße 9-13, 44787 Bochum, Germany.
Nexus-Klinik Baden-Baden, Hermann-Sielcken-Straße 80, 76530 Baden-Baden, Germany.
Pilot Feasibility Stud. 2018 Aug 4;4:133. doi: 10.1186/s40814-018-0325-1. eCollection 2018.
Enhancing the capacity to experience positive affect could help improve recovery across a range of areas of mental health. Experimental psychopathology research indicates that a computerized cognitive training paradigm involving generation of positive mental imagery can increase state positive affect, and more recent clinical studies have suggested that this training could be used as an adjunct treatment module to target symptoms related to positive affect deficits, specifically anhedonia. The current study investigates the feasibility of adding a positive mental imagery computerized training module to treatment for patients in inpatient mental health settings, with a focus on increasing positive affect and reducing anhedonia. The positive mental imagery training (PMIT) is added to treatment as usual (TAU) in the inpatient setting, and compared to TAU alone, or TAU plus an alternative cognitive training module not hypothesized to increase positive affect, cognitive control training (CCT).
The study is a feasibility randomized controlled trial with three parallel arms. Up to 90 patients admitted to inpatient mental health treatment clinics in Germany will be randomized to PMIT + TAU, CCT + TAU, or TAU on a 1:1:1 ratio. PMIT or CCT consist of an introductory session followed by up to 8 full training sessions over 2 weeks. All three arms (including TAU) include regular completion of mood measures over the 2-week period. Outcome measures are completed pre and post this 2-week training/monitoring period, and at 2-week follow-up. Data will be presented in the form of both raw means and standardized effect sizes, with 95% confidence intervals, for both intention-to-treat and per-protocol samples.
The study will inform feasibility of conducting a fully powered randomized controlled trial investigating the addition of the positive mental imagery training as a treatment adjunct to inpatient treatments for mental health, including potential refinement of study procedures, inclusion/exclusion criteria, and preliminary indications of the likely range of effect sizes.
clinicaltrials.gov, NCT02958228 (date registered: 4 November 2016).
增强体验积极情绪的能力有助于改善心理健康多个领域的恢复情况。实验性精神病理学研究表明，一种涉及生成积极心理意象的计算机化认知训练范式能够增加状态积极情绪，并且最近的临床研究表明，这种训练可作为一种辅助治疗模块，用于针对与积极情绪缺陷相关的症状，特别是快感缺乏。本研究调查了在住院心理健康环境中为患者的治疗添加积极心理意象计算机化训练模块的可行性，重点是增加积极情绪和减少快感缺乏。在住院环境中，将积极心理意象训练（PMIT）添加到常规治疗（TAU）中，并与单独的TAU或TAU加一个未被假设能增加积极情绪的替代认知训练模块，即认知控制训练（CCT）进行比较。
该研究是一项可行性随机对照试验，有三个平行组。德国住院心理健康治疗诊所收治的多达90名患者将按1:1:1的比例随机分配到PMIT + TAU、CCT + TAU或TAU组。PMIT或CCT包括一次介绍性课程，随后在2周内进行多达8次完整的训练课程。所有三组（包括TAU）在这2周期间都要定期完成情绪测量。在这2周的训练/监测期前后以及2周随访时完成结局测量。数据将以原始均值和标准化效应量的形式呈现，并带有95%置信区间，用于意向性分析样本和符合方案样本。
该研究将为开展一项充分有力的随机对照试验提供可行性信息，该试验旨在研究添加积极心理意象训练作为心理健康住院治疗的辅助治疗方法，包括研究程序、纳入/排除标准的潜在优化，以及效应量可能范围的初步迹象。
clinicaltrials.gov，NCT02958228（注册日期：2016年11月4日）。
