CCVC, PROTEO, Département de chimie, Université Laval, 1045 avenue de la Médecine, Québec, Québec G1V 0A6, Canada.
Chem Commun (Camb). 2018 Sep 11;54(73):10224-10239. doi: 10.1039/c8cc05108a.
C-F bond activation has drawn a lot of attention in the past, and the case of C(sp3)-F bonds is particularly interesting as those are the strongest single bonds carbon makes with any other element. This Feature Article aims at highlighting our work and that of others on the successful approaches that led to the activation of such C-F bonds at benzylic, allylic, propargylic and allenylic positions, for both mono- and polyfluorides. We now hope that this will set ground for discussions, contribute to fostering new ideas, and thus help in pushing current frontiers further.
C-F 键的活化在过去引起了广泛关注，而 C(sp3)-F 键的情况尤其有趣，因为它们是碳与任何其他元素形成的最强单键。本文旨在强调我们和其他人在成功活化苄基、烯丙基、炔丙基和 allenyl 位的单氟和多氟化物的 C-F 键方面的工作。我们现在希望这将为讨论奠定基础，有助于培养新的想法，从而有助于进一步推动当前的前沿研究。
