Psychopharmacology Research Unit, University Department of Psychiatry, University of Oxford, Oxford, United Kingdom.
Oxford Health NHS Foundation Trust, Warneford Hospital, Warneford Lane, Oxford, United Kingdom.
Int J Neuropsychopharmacol. 2018 Nov 1;21(11):988-996. doi: 10.1093/ijnp/pyy069.
Identification of biomarkers predicting therapeutic outcome of antidepressant treatment is one of the most important tasks in current research because it may transform the lengthy process of finding the right treatment for a given individual with depression. In the current study, we explored the potential of pretreatment pregenual anterior cingulate cortex activity as a putative biomarker of treatment response.
Thirty-two medication-free patients with depression were treated for 6 weeks with a selective serotonin reuptake inhibitor, escitalopram. Before treatment began, patients underwent an fMRI scan testing response to brief, masked, presentations of facial expression depicting sadness and happiness.
After 6 weeks of treatment, there were 20 selective serotonin reuptake inhibitor responders and 12 nonresponders. Increased pretreatment pregenual anterior cingulate cortex activity to sad vs happy faces was observed in responders relative to nonresponders. A leave-one-out analysis suggested that activity in the anterior cingulate cortex was able to predict response status at the level of the individual participant.
The study supports the notion of pregenual anterior cingulate cortex as a promising predictor of antidepressant response.
识别预测抗抑郁治疗效果的生物标志物是当前研究的最重要任务之一，因为它可能会缩短为特定抑郁症患者找到合适治疗方法的漫长过程。在本研究中，我们探讨了预处理扣带前回活动作为治疗反应的潜在生物标志物的可能性。
32 名未经药物治疗的抑郁症患者接受选择性 5-羟色胺再摄取抑制剂依他普仑治疗 6 周。在开始治疗之前，患者接受了 fMRI 扫描测试，以测试对短暂、掩蔽、呈现表示悲伤和快乐的面部表情的反应。
经过 6 周的治疗，有 20 名选择性 5-羟色胺再摄取抑制剂反应者和 12 名非反应者。与非反应者相比，反应者的预处理扣带前回对悲伤与快乐面孔的活动增加。一项留一法分析表明，前扣带回皮质的活动能够预测个体参与者的反应状态。
该研究支持扣带前回作为抗抑郁反应的有前途的预测因子的观点。
