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长链非编码RNA FLJ46906与转录因子NF-κB和AP-1结合，并调节衰老相关基因的表达。

The long non-coding RNA FLJ46906 binds to the transcription factors NF-κB and AP-1 and regulates expression of aging-associated genes.

作者信息

Yo Kazuyuki, Rünger Thomas M

机构信息

Department of Dermatology, Boston University School of Medicine, Boston, MA 02118, USA.

Current address: Dermatological R & D, POLA Chemical Industries Inc., Yokohama, Japan.

出版信息

Aging (Albany NY). 2018 Aug 17;10(8):2037-2050. doi: 10.18632/aging.101528.

DOI:10.18632/aging.101528
PMID:30125263
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6128423/
Abstract

Several features differentiate aged cells from young cells, many of which are due to changes in gene expression during the aging process. The mechanisms of altered gene expression in aging cells remain incompletely understood, and we hypothesized that long non-coding (lnc) RNAs mediate at least some of these changes. We screened for alterations in lncRNA expression with aging in skin fibroblasts and identified the lncRNA FLJ46906 to be consistently upregulated with aging in-vivo and in-vitro. The function of this lncRNA has not been known. Here we show that FLJ46906 regulates several aging-associated genes, including , , , and We suggest that these effects are mediated through NF-κB and AP-1, because these aging-associated genes are regulated by NF-κB and AP-1, and because we found that FLJ46906 directly binds to these two transcription factors. This data supports a role of the lncRNA FLJ46906 in the aging process.

摘要

衰老细胞与年轻细胞在几个特征上存在差异，其中许多差异归因于衰老过程中基因表达的变化。衰老细胞中基因表达改变的机制仍未完全了解，我们推测长链非编码（lnc）RNA至少介导了其中一些变化。我们筛选了皮肤成纤维细胞衰老过程中lncRNA表达的变化，并确定lncRNA FLJ46906在体内和体外均随衰老而持续上调。这种lncRNA的功能尚不清楚。在此我们表明，FLJ46906调节多个与衰老相关的基因，包括 、 、 、 和 。我们认为这些作用是通过NF-κB和AP-1介导的，因为这些与衰老相关的基因受NF-κB和AP-1调节，并且我们发现FLJ46906直接与这两个转录因子结合。这些数据支持lncRNA FLJ46906在衰老过程中发挥作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fb9/6128423/184a8d0f40fe/aging-10-101528-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fb9/6128423/c404ab8cc38b/aging-10-101528-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fb9/6128423/53208c30de8d/aging-10-101528-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fb9/6128423/7cacf5e5a1b4/aging-10-101528-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fb9/6128423/184a8d0f40fe/aging-10-101528-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fb9/6128423/c404ab8cc38b/aging-10-101528-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fb9/6128423/53208c30de8d/aging-10-101528-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fb9/6128423/7cacf5e5a1b4/aging-10-101528-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fb9/6128423/184a8d0f40fe/aging-10-101528-g004.jpg

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