Wagner Tobias, Augustin Matthias, Blome Christine, Forschner Andrea, Garbe Claus, Gutzmer Ralf, Hauschild Axel, Heinzerling Lucie, Livingstone Elisabeth, Loquai Carmen, Schadendorf Dirk, Terheyden Patrick, Mueller-Brenne Tina, Kähler Katharina C
German Center for Health Services Research in Dermatology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Department of Dermatology, Eberhard-Karls University of Tuebingen, Tuebingen, Germany.
Eur J Cancer Care (Engl). 2018 Sep;27(5):e12901. doi: 10.1111/ecc.12901. Epub 2018 Aug 20.
We aimed to determine the prevalence and importance of fear of cancer progression (FoP) in melanoma patients with stage IA tumours to assess psychosocial and demographic factors associated with severity of FoP and to determine the relationship of FoP and quality of life (QoL). One hundred and thirty-six patients with stage IA melanoma completed the short version of the Fear of Progression Questionnaire (FoP-Q-SF), the Hospital Anxiety and Depression Scale (HADS) and the EORTC-QLQ-C30. We found a mean FoP-Q-SF sum score of 30.2 points (±8.4 points SD). In this study, 33% of patients reported high FoP at or above the cutoff-value of 34 points. Higher FoP was found in women (p < 0.01), young (p = 0.03) and employed (p = 0.02) patients. Being confronted with a cancer diagnosis in closely related persons predicted higher FoP (p < 0.01). FoP correlated positively with the HADS anxiety (r = 0.50, p < 0.01) and depression scales (r = 0.26, p < 0.01) and negatively with the EORTC-QLQ-C30 global health state (r = -0.32, p < 0.01). FoP is considerably prevalent in low-risk melanoma patients and associated with reduced QoL, cancer in related persons, women sex and participation in working life. Considerably high levels of FoP, even in patients with low-risk malignancies, underline the need for psychosocial support and psychotherapeutic interventions for melanoma patients.
我们旨在确定IA期肿瘤黑色素瘤患者中癌症进展恐惧（FoP）的患病率和重要性，以评估与FoP严重程度相关的心理社会和人口统计学因素，并确定FoP与生活质量（QoL）的关系。136例IA期黑色素瘤患者完成了癌症进展恐惧问卷简版（FoP-Q-SF）、医院焦虑抑郁量表（HADS）和欧洲癌症研究与治疗组织生活质量核心问卷（EORTC-QLQ-C30）。我们发现FoP-Q-SF总分平均为30.2分（标准差±8.4分）。在本研究中，33%的患者报告FoP高于或等于34分的临界值。女性（p<0.01）、年轻患者（p=0.03）和在职患者（p=0.02）的FoP更高。与密切相关的人被诊断患有癌症会导致更高的FoP（p<0.01）。FoP与HADS焦虑量表（r=0.50，p<0.01）和抑郁量表（r=0.26，p<0.01）呈正相关，与EORTC-QLQ-C30总体健康状况呈负相关（r=-0.32，p<0.01）。FoP在低风险黑色素瘤患者中相当普遍，并且与生活质量降低、相关人员患癌症、女性性别和参与工作生活有关。即使在低风险恶性肿瘤患者中，FoP水平也相当高，这突出了对黑色素瘤患者进行心理社会支持和心理治疗干预的必要性。
