Navarro-Quiles Carla, Mateo-Bonmatí Eduardo, Micol José L
Instituto de Bioingeniería, Universidad Miguel Hernández, Elche, Spain.
Front Plant Sci. 2018 Aug 3;9:1125. doi: 10.3389/fpls.2018.01125. eCollection 2018.
Most members of the large family of ATP-Binding Cassette (ABC) proteins function as membrane transporters. However, the most evolutionarily conserved group, the ABCE protein subfamily, comprises soluble proteins that were initially denoted RNase L inhibitor (RLI) proteins. ABCE proteins are present in all eukaryotes and archaea and are encoded by a single gene in most genomes, or by two genes in a few cases. Functional analysis of genes, primarily in , has shown that ABCE proteins have essential functions as part of the translational apparatus. In this review, we summarize the current understanding of ABCE protein function in ribosome biogenesis and recycling, with a particular focus on their known and proposed developmental roles in different species. The ABCE proteins might represent another class of factors contributing to the role of the ribosome in gene expression regulation.
三磷酸腺苷结合盒（ABC）蛋白大家族的大多数成员都作为膜转运蛋白发挥作用。然而，进化上最保守的组，即ABCE蛋白亚家族，由最初被称为核糖核酸酶L抑制剂（RLI）蛋白的可溶性蛋白组成。ABCE蛋白存在于所有真核生物和古细菌中，在大多数基因组中由单个基因编码，少数情况下由两个基因编码。主要在[具体物种未给出]中对[具体基因未给出]基因的功能分析表明，ABCE蛋白作为翻译装置的一部分具有重要功能。在这篇综述中，我们总结了目前对ABCE蛋白在核糖体生物发生和循环中的功能的理解，特别关注它们在不同物种中已知的和推测的发育作用。ABCE蛋白可能代表了另一类有助于核糖体在基因表达调控中发挥作用的因子。
