Wang Junnan, Wang Yiran, Long Fei, Yan Fengshang, Wang Ning, Wang Yajie
Basic Medical College, Navy Medical University, Shanghai, China.
Changhai Hospital, Navy Medical University, Shanghai, China.
PeerJ. 2018 Aug 15;6:e5344. doi: 10.7717/peerj.5344. eCollection 2018.
Growth arrest and DNA-damage-inducible protein 45 alpha (GADD45A) was previously found to be associated with risk of several kinds of human tumors. Here, we studied the expression and clinical significance of GADD45A in breast cancer.
We performed an immunohistochemical study of GADD45A protein from 419 breast cancer tissues and 116 adjacent non-neoplastic tissues.
Significantly high GADD45A expression were observed in breast cancer tissues compared with adjacent non-neoplastic tissues ( < 0.001) and were independently correlative with estrogen receptor negative ( = 0.028) and high Ki-67 index ( < 0.001). Kaplan-Meier survival analysis revealed that patients with high GADD45A expression levels had a worse long-term prognosis in triple negative breast cancer ( = 0.041), but it was not an independent prognostic factor in multivariate analysis ( = 0.058).
GADD45A expression levels are significantly correlative with estrogen receptor status and Ki-67 index in human breast cancer. Patients with triple negative breast cancer might be stratified into high risk and low risk groups based on the GADD45A expression levels.
生长停滞和DNA损伤诱导蛋白45α（GADD45A）先前被发现与几种人类肿瘤的风险相关。在此，我们研究了GADD45A在乳腺癌中的表达及临床意义。
我们对419例乳腺癌组织和116例相邻非肿瘤组织中的GADD45A蛋白进行了免疫组织化学研究。
与相邻非肿瘤组织相比，乳腺癌组织中观察到GADD45A表达显著升高（<0.001），且与雌激素受体阴性（=0.028）和高Ki-67指数（<0.001）独立相关。Kaplan-Meier生存分析显示，GADD45A表达水平高的患者在三阴性乳腺癌中的长期预后较差（=0.041），但在多变量分析中它不是独立的预后因素（=0.058）。
GADD45A表达水平与人乳腺癌中的雌激素受体状态和Ki-67指数显著相关。三阴性乳腺癌患者可能根据GADD45A表达水平分为高风险和低风险组。
