Jackson Christopher D, Clanahan Michael J, Joglekar Kiran, Decha-Umphai Sorawit T
Internal Medicine, University of Tennessee Health Science Center Memphis.
Internal Medicine, Mercy Clinic Internal Medicine, St Louis, USA.
Cureus. 2018 Mar 4;10(3):e2269. doi: 10.7759/cureus.2269.
A drug-induced liver injury is one of the most common causes of acute liver failure. While acetaminophen is the most common etiology, other offending medications include amoxicillin-clavulanic acid, amiodarone, isoniazid, and fluoroquinolones to name a few. Gabapentin, a gamma-aminobutyric acid (GABA) analogue, has infrequently been reported to cause liver injury; however, the causality in the previous reports is contested. Herein, we report a gabapentin-induced hepatocellular injury in a patient without another identifiable cause for acute liver injury. Discontinuing gabapentin resulted in rapid reversal improvement in hepatocellular injury.
药物性肝损伤是急性肝衰竭最常见的病因之一。虽然对乙酰氨基酚是最常见的病因，但其他致病药物包括阿莫西林-克拉维酸、胺碘酮、异烟肼和氟喹诺酮等。加巴喷丁是一种γ-氨基丁酸（GABA）类似物，很少被报道会导致肝损伤；然而，先前报道中的因果关系存在争议。在此，我们报告一例无其他可识别的急性肝损伤病因的患者发生加巴喷丁所致的肝细胞损伤。停用加巴喷丁后，肝细胞损伤迅速逆转改善。
