Viguera Cristina, Wang Jiangxia, Mosmiller Elizabeth, Cerezo Aiana, Maragakis Nicholas J
School of Medicine Johns Hopkins University Baltimore Maryland.
Johns Hopkins Bloomberg School of Public Health Baltimore Maryland.
Ann Clin Transl Neurol. 2018 Jun 19;5(8):976-981. doi: 10.1002/acn3.594. eCollection 2018 Aug.
We utilized the well-validated University of Pennsylvania Smell Identification Test (UPSIT) to examine whether olfactory dysfunction occurs in ALS participants. After adjusting for relevant confounders in a multiple linear regression model, ALS participants scored significantly lower on the UPSIT compared with control participants, with an estimated mean difference of 2.31 points ( = 0.015). ALS participants also had twice the rate of olfactory dysfunction (microsmia or anosmia). This study suggests that olfactory dysfunction exists in ALS patients, which expands our understanding of the extramotor findings in ALS. Future investigations could determine whether there are correlations between olfactory dysfunction and specific ALS phenotypes.
我们采用经过充分验证的宾夕法尼亚大学嗅觉识别测试（UPSIT）来检查肌萎缩侧索硬化症（ALS）患者是否存在嗅觉功能障碍。在多元线性回归模型中对相关混杂因素进行调整后，ALS患者在UPSIT上的得分显著低于对照组，估计平均差异为2.31分（P = 0.015）。ALS患者嗅觉功能障碍（嗅觉减退或嗅觉丧失）的发生率也高出两倍。这项研究表明ALS患者存在嗅觉功能障碍，这扩展了我们对ALS患者运动外表现的理解。未来的研究可以确定嗅觉功能障碍与特定ALS表型之间是否存在关联。
