School of Chemistry and Chemical Engineering, Yancheng Institute of Technology, Yancheng, 224051, China.
Mikrochim Acta. 2018 Aug 20;185(9):422. doi: 10.1007/s00604-018-2961-9.
The authors describe the synthesis of fluorescent coral-like carbon nano-branched polymers (PCNBPs) co-doped with nitrogen and phosphorus. Uric acid and phosphoric acid act as nitrogen and phosphorus sources, respectively. The PCNBPs have a coral-like branched structure, are cross-connected, and < 20 nm in skeleton diameter. Their blue fluorescence, best measured at excitation/emission wavelengths of 330/425 nm, is quenched by mercury (II) ions due to the specifically restricted rigid conformation caused by the interaction of phosphorus, nitrogen, and oxygen groups on the surface of the PCNBPs. Fluorescence is selectivity quenched by Hg(II) but restored in addition of the hypertension drug captopril (CAP) in the range 50 nM to 40 μM concentration range. Fluorescence recovery is attributed to the effectively specific interactions between the thiol group of CAP and Hg(II). The method was applied to the determination of the concentration of Cap in pharmaceutical samples, and recoveries were between 97.6 and 105.1%. Graphical abstract Fluorescent coral-like carbon nano-branched polymers (PCNBPs) co-doped with nitrogen and phosphorus are described. Their fluorescence is selectivity quenched by Hg(II) but restored in addition of the hypertension drug captopril (Cap) in the range 50 nM to 40 μM concentration range.
作者描述了氮磷共掺杂荧光珊瑚状碳纳米支化聚合物（PCNBPs）的合成。尿酸和磷酸分别作为氮和磷源。PCNBPs 具有珊瑚状分支结构，相互交联，骨架直径<20nm。其最佳激发/发射波长为 330/425nm 的蓝色荧光由于磷、氮和氧基团在 PCNBPs 表面的相互作用而被汞（II）离子特异性限制刚性构象所猝灭。荧光被 Hg(II) 选择性猝灭，但在添加高血压药物卡托普利（CAP）后在 50nM 至 40μM 浓度范围内得到恢复。荧光恢复归因于 CAP 的巯基与 Hg(II) 之间的有效特异性相互作用。该方法用于测定药物样品中 Cap 的浓度，回收率在 97.6%至 105.1%之间。
