Charruyer Alexandra, Ghadially Ruby
Curr Probl Dermatol. 2018;54:71-78. doi: 10.1159/000489520. Epub 2018 Aug 21.
Intracellular pH influences proliferation and differentiation in a range of stem-like and progenitor cells, including embryonic stem cells, induced pluripotent stem cells, mesenchymal stem cells, and cancer stem cells. Sodium hydrogen exchanger (NHE1), a glycoprotein that plays a major role in regulating intracellular pH, has a major role in the proliferation and cell differentiation in multiple cell types. We review observations collected on the influence of pH on multiple stem-like cell populations. Altering pH, either intracellular or extracellular, can influence stem cell maintenance, self-renewal, differentiation, and pluripotency. Study of the influence of NHE1 and intracellular pH on epidermal stem cell behavior could lead to the discovery of new targets to use in order to manipulate stem cell divisions. This is highly relevant for skin conditions such as psoriasis, wound healing, and melanoma where stem cell proliferation and migration are key factors.
细胞内pH值会影响一系列类干细胞和祖细胞的增殖与分化，这些细胞包括胚胎干细胞、诱导多能干细胞、间充质干细胞和癌症干细胞。钠氢交换体（NHE1）是一种在调节细胞内pH值方面起主要作用的糖蛋白，在多种细胞类型的增殖和细胞分化中发挥着重要作用。我们综述了关于pH值对多个类干细胞群体影响的观察结果。改变细胞内或细胞外的pH值，会影响干细胞的维持、自我更新、分化和多能性。研究NHE1和细胞内pH值对表皮干细胞行为的影响，可能会发现用于操控干细胞分裂的新靶点。这对于银屑病、伤口愈合和黑色素瘤等皮肤疾病极具相关性，因为在这些疾病中干细胞增殖和迁移是关键因素。
