Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Br J Pharmacol. 2020 Nov;177(22):5008-5030. doi: 10.1111/bph.15242. Epub 2020 Sep 28.
In recent years, phase separation has been increasingly reported to play a pivotal role in a wide range of biological processes. Due to the close relationships between cancer and disorders in intracellular physiological function, the identification of new mechanisms involved in intracellular regulation has been regarded as a new direction for cancer therapy. Introducing the concept of phase separation into complex descriptions of disease mechanisms may provide many different insights. Here, we review the recent findings on the phase separation of cancer-related proteins, describing the possible relationships between phase separation and key proteins associated with cancer and indicate possible regulatory modalities, especially drug candidates for phase separation, which may provide more effective strategies for cancer therapy.
近年来，液-液相分离在广泛的生物过程中发挥关键作用的报道越来越多。由于癌症与细胞内生理功能障碍密切相关，因此鉴定参与细胞内调控的新机制被认为是癌症治疗的新方向。将液-液相分离的概念引入到疾病机制的复杂描述中可能会提供许多不同的见解。在这里，我们综述了与癌症相关的蛋白质液-液相分离的最新发现，描述了液-液相分离与癌症相关的关键蛋白之间可能存在的关系，并指出了可能的调控模式，特别是液-相分离的药物候选物，这可能为癌症治疗提供更有效的策略。
