Schürer Nanna
Curr Probl Dermatol. 2018;54:115-122. doi: 10.1159/000489525. Epub 2018 Aug 21.
Acne is based on a complex, multifactorial pathophysiology beginning with a microcomedo. Comedogenesis involves follicular hyperproliferation and disturbed keratinization, hyperseborrhea and hyperplasia of sebaceous glands as well as disturbances in skin microbiome. Acne is treated with antibiotics, retinoids, keratolytics, hormonal and anti-inflammatory agents. Efficacy and side effects of given medications are well known. The uppermost layer of the stratum corneum is acidic. The low pH provides protection by slowing down the growth of some bacteria. Increase of skin surface pH leads to impaired barrier function, disturbances in skin microbiome and inflammation. Acne-predisposed skin is in a constant state of subclinical inflammation. Subclinical inflammation may be linked to changes in skin surface pH and disturbances of the stratum corneum, allowing microorganisms to stimulate the production of pro-inflammatory cytokines. Here, based on the current literature, the possible link between the skin surface pH, epidermal barrier function and acne is reviewed.
痤疮基于一种复杂的、多因素的病理生理学过程，始于微粉刺。粉刺形成涉及毛囊过度增殖和角化紊乱、皮脂溢出和皮脂腺增生以及皮肤微生物群紊乱。痤疮的治疗药物包括抗生素、维甲酸、角质溶解剂、激素和抗炎药。已知这些药物的疗效和副作用。角质层的最上层呈酸性。低pH值通过减缓某些细菌的生长提供保护。皮肤表面pH值升高会导致屏障功能受损、皮肤微生物群紊乱和炎症。易患痤疮的皮肤处于持续的亚临床炎症状态。亚临床炎症可能与皮肤表面pH值变化和角质层紊乱有关，使微生物能够刺激促炎细胞因子的产生。在此，基于当前文献，综述了皮肤表面pH值、表皮屏障功能与痤疮之间可能的联系。
