Wecke J, Lahav M, Ginsburg I, Kwa E, Giesbrecht P
Arch Microbiol. 1986 Mar;144(2):110-5. doi: 10.1007/BF00414719.
Liquoid (polyanethole sulfonate) was neither capable of influencing the growth nor the viability of staphylococci. But liquoid induced a suppression of the activity of different autolytic wall systems of normally growing staphylococci, i.e., autolysins which participate in cross wall separation as well as autolysins which are responsible for cell wall turnover. Additionally, the lysostaphin-induced wall disintegration of staphylococci was inhibited by liquoid. However, no indication could be found for a direct inhibition of lytic wall enzymes by liquoid; rather an interaction of liquoid with the target structure for the autolytic wall enzymes, the cell wall itself, was postulated. On the basis of the experimental data with the teichoic acid- mutant S. aureus 52A5 the sites of wall teichoic acid were supposed to be an important target for the binding of liquoid to the staphylococcal cell wall.
多聚茴香脑磺酸钠对葡萄球菌的生长和生存能力均无影响。但多聚茴香脑磺酸钠可抑制正常生长的葡萄球菌不同自溶壁系统的活性，即参与横壁分离的自溶素以及负责细胞壁周转的自溶素。此外，多聚茴香脑磺酸钠可抑制溶葡萄球菌素诱导的葡萄球菌细胞壁解体。然而，未发现多聚茴香脑磺酸钠对细胞壁裂解酶有直接抑制作用；而是推测多聚茴香脑磺酸钠与自溶壁酶的靶结构即细胞壁本身存在相互作用。基于对磷壁酸突变体金黄色葡萄球菌52A5的实验数据，推测细胞壁磷壁酸位点是多聚茴香脑磺酸钠与葡萄球菌细胞壁结合的重要靶点。
