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具有改变的磷壁酸组成的肺炎球菌中的异常自溶酶。

Abnormal autolytic enzyme in a pneumococus with altered teichoic acid composition.

作者信息

Tomasz A, Westphal M

出版信息

Proc Natl Acad Sci U S A. 1971 Nov;68(11):2627-30. doi: 10.1073/pnas.68.11.2627.

DOI:10.1073/pnas.68.11.2627
PMID:4399413
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC389487/
Abstract

Pneumococci in which the choline component of the cell wall teichoic acid was replaced by ethanolamine contain an abnormal autolytic enzyme that has a low molecular weight and low activity in contrast to the enzyme typical of choline-containing bacteria that has a high molecular weight and high activity. The abnormal autolysin can be converted to the normal (cholinetype) enzyme by incubation in vitro with choline-containing cell walls.

摘要

细胞壁磷壁酸的胆碱成分被乙醇胺取代的肺炎球菌含有一种异常的自溶酶，该酶分子量低且活性低，这与含胆碱细菌典型的分子量高且活性高的酶形成对比。通过在体外与含胆碱的细胞壁一起孵育，这种异常的自溶素可以转化为正常的（胆碱型）酶。

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本文引用的文献

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Effect of teichoic acid on resistance to the membrane-lytic agent of Streptococcus zymogenes.磷壁酸对发酵链球菌抗膜溶解剂能力的影响。
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The autolytic enzyme system of Streptococcus faecalis. II. Partial characterization of the autolysin and its substrate.粪链球菌的自溶酶系统。II. 自溶素及其底物的部分特性
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Choline-containing teichoic acid as a structural component of pneumococcal cell wall and its role in sensitivity to lysis by an autolytic enzyme.含胆碱磷壁酸作为肺炎球菌细胞壁的结构成分及其在对自溶酶裂解敏感性中的作用。
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Biological consequences of the replacement of choline by ethanolamine in the cell wall of Pneumococcus: chanin formation, loss of transformability, and loss of autolysis.肺炎球菌细胞壁中乙醇胺取代胆碱的生物学后果：链菌素形成、转化能力丧失和自溶作用丧失。
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Properties of a novel pleiotropic bacteriophage-resistant mutant of Staphylococcus aureus H.金黄色葡萄球菌H的一种新型多效性噬菌体抗性突变体的特性
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