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细菌细胞壁的调控:金黄色葡萄球菌中细胞壁的周转

Regulation of bacterial cell walls: turnover of cell wall in Staphylococcus aureus.

作者信息

Wong W, Young F E, Chatterjee A N

出版信息

J Bacteriol. 1974 Nov;120(2):837-43. doi: 10.1128/jb.120.2.837-843.1974.

Abstract

The cell wall of Staphylococcus aureus was shown to undergo turnover during exponential growth. The rate of turnover, about 15% per generation, was identical for both cell wall polymers, peptidoglycan and teichoic acid. Both the old and newly synthesized wall material appeared to undergo turnover at similar rates. The rate of turnover followed first-order kinetics until more than 90% of the original wall was lost. Cell wall turnover was completely blocked under conditions of unbalanced synthesis known to inhibit cellular autolysis, e.g., addition of chloramphenicol. Cell wall turnover was shown to occur in a number of different strains of S. aureus and appears to be widely distributed in this species.

摘要

金黄色葡萄球菌的细胞壁在指数生长期会发生更新。两种细胞壁聚合物(肽聚糖和磷壁酸)的更新速率相同,约为每代15%。旧的和新合成的壁物质似乎以相似的速率进行更新。更新速率遵循一级动力学,直到超过90%的原始细胞壁丢失。在已知抑制细胞自溶的不平衡合成条件下,如添加氯霉素,细胞壁更新会完全受阻。已证明细胞壁更新发生在多种不同的金黄色葡萄球菌菌株中,并且似乎在该物种中广泛存在。

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