Faltová E, Mráz M, Procházka J, Sedivý J
Physiol Bohemoslov. 1980;29(4):305-12.
The authors studed the effect of pregnancy and lactation on the resistance of myocardium against damage. Lesions of the heart were induced by isoprenaline in vivo. The extent of lesions was evaluated macroscopically and quantitatively according to the increased accumulation of 203HCl2 in the damaged heart tissue. In vitro, the damage of the isolated right ventricle was induced by anoxia and the resistance of heart tissue was evaluated according to the recovery of contractility. During the first week after delivery, the extent of isoprenaline-induced heart lesions was increased in nursing mothers as compared with virgin females of the same age. The mortality did not change significantly. Restitution of contractility of the right ventricle in vitro and anoxia was lower than in virgin females. In nursing mothers 35 days after delivery, the mortality and the extent of heart lesions induced by isoprenaline was significantly reduced as compared with virgin females. Furthermore, the resistance to anoxia of their isolated right ventricle was higher than that of virgin females. The reduced effect of isoprenaline lasted for several months after devlivery. The mortality and the extent of isoprenaline-induced heart lesions were not reduced significantly 35 days after delivery in non-lactating mothers, which were deprived of their young.
作者研究了妊娠和哺乳期对心肌抗损伤能力的影响。通过在体内注射异丙肾上腺素诱导心脏损伤。根据受损心脏组织中203HCl2积累的增加情况，宏观且定量地评估损伤程度。在体外，通过缺氧诱导离体右心室损伤，并根据收缩性的恢复情况评估心脏组织的抗损伤能力。在分娩后的第一周，与同龄未生育雌性相比，哺乳母亲中异丙肾上腺素诱导的心脏损伤程度增加。死亡率没有显著变化。体外右心室在缺氧情况下的收缩性恢复低于未生育雌性。在分娩后35天的哺乳母亲中，与未生育雌性相比，异丙肾上腺素诱导的死亡率和心脏损伤程度显著降低。此外，她们离体右心室的抗缺氧能力高于未生育雌性。异丙肾上腺素的这种减弱作用在分娩后持续数月。在分娩后35天，剥夺幼崽的非哺乳母亲中，异丙肾上腺素诱导的死亡率和心脏损伤程度没有显著降低。
