Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, No. 866 Yuhangtang Road, Hangzhou, 310058, China.
Amino Acids. 2018 Nov;50(11):1637-1646. doi: 10.1007/s00726-018-2631-6. Epub 2018 Aug 21.
The objective of the study was to investigate how taurine alleviates mucosal injury. Young chickens were fed with taurine for 1 week and then challenged with lipopolysaccharide. We found that, under lipopolysaccharide challenge, taurine could attenuate diarrhea and mucosal inflammation. Additionally, under LPS challenge, taurine could enhance epithelial proliferation and goblet cell function, could also decrease epithelial apoptosis by improving the mitochondrial membrane permeability. The high-performance liquid chromatography assay showed that taurine feeding could elevate taurine concentration in duodenum obviously. The antioxidant assay showed that taurine could reverse lipopolysaccharide-induced low GSH level, GSH/GSSG ratio, GSH-Px activity and SOD activity, high GSSG and MDA content. In summary, we suggested that taurine could enhance duodenal antioxidant status locally and further ameliorated lipopolysaccharide-induced chicken duodenal inflammation by improving mitochondrial membrane permeability and goblet cell function.
本研究旨在探讨牛磺酸如何缓解黏膜损伤。将幼鸡用牛磺酸喂养 1 周，然后用脂多糖进行攻毒。我们发现，在脂多糖攻毒下，牛磺酸可以减轻腹泻和黏膜炎症。此外，在 LPS 攻毒下，牛磺酸可以通过改善线粒体膜通透性来增强上皮细胞增殖和杯状细胞功能，还可以减少上皮细胞凋亡。高效液相色谱分析显示，牛磺酸喂养可明显提高十二指肠牛磺酸浓度。抗氧化分析显示，牛磺酸可逆转脂多糖诱导的低 GSH 水平、GSH/GSSG 比值、GSH-Px 活性和 SOD 活性、高 GSSG 和 MDA 含量。总之，我们认为牛磺酸可以增强十二指肠局部抗氧化状态，并通过改善线粒体膜通透性和杯状细胞功能，进一步改善脂多糖诱导的鸡十二指肠炎症。
