Zhang Jian, Ao Yun-Lin, Yao Nan, Bai Wen-Xin, Fan Chun-Lin, Ye Wen-Cai, Zhang Xiao-Qi
Institute of Traditional Chinese Medicine & Natural Products, and Guangdong Provincial Engineering Research Center for Modernization of TCM, College of Pharmacy, Jinan University, Guangzhou, 510632, P. R. China.
Chem Biodivers. 2018 Oct;15(10):e1800268. doi: 10.1002/cbdv.201800268. Epub 2018 Oct 7.
Three new monoterpenoid indole alkaloids, ervapandine A (1), (3R)-hydroxyibogaine (3), 12-hydroxyakuammicine N(4)-oxide (6), along with four known ones, were isolated from the twigs and leaves of Ervatamia pandacaqui. The structures of the new alkaloids were elucidated by spectroscopic methods and sugar hydrolysis experiment. All of the compounds were evaluated for their cytotoxicity against three human cell lines. Compound 7 showed moderate cytotoxic activity.
从广西狗牙花（Ervatamia pandacaqui）的嫩枝和叶子中分离出三种新的单萜吲哚生物碱，即二氢鸭脚木碱A（1）、（3R）-羟基伊博格碱（3）、12-羟基阿枯米辛N（4）-氧化物（6），以及四种已知生物碱。通过光谱方法和糖水解实验阐明了新生物碱的结构。对所有化合物针对三种人类细胞系的细胞毒性进行了评估。化合物7表现出中等程度的细胞毒性活性。
