Research Center, Chengdu Medical College, Chengdu 610083, Sichuan, P. R. China.
Org Lett. 2012 Jul 6;14(13):3450-3. doi: 10.1021/ol301400e. Epub 2012 Jun 8.
Calophyline A (1), a novel unprecedented rearranged monoterpenoid indole alkaloid, along with a new natural product N-methyl aspidodasycarpine (2) and six known analogues, was isolated from the trunk barks of Winchia calophylla. The structure of compound 1 was elucidated on the basis of spectroscopic data and then confirmed by a single-crystal X-ray crystallographic analysis. A hypothetical biogenetic pathway for compound 1 was proposed. All isolated compounds were evaluated for their in vitro cytotoxicity against a small panel of human cancer cell lines.
从轮叶翅子木（Winchia calophylla）的树干皮中分离得到了 1 个新型前所未有的重排单萜吲哚生物碱 calophyline A（1），以及 1 个新的天然产物 N-甲基阿朴蝶斯卡林（2）和 6 个已知类似物。根据光谱数据阐明了化合物 1 的结构，然后通过单晶 X 射线晶体学分析得到了证实。提出了化合物 1 的假设生物合成途径。所有分离得到的化合物均对小panel 的人类癌细胞系进行了体外细胞毒性评价。
