Dasinger John Henry, Fehrenbach Daniel J, Abais-Battad Justine M
Department of Physiology, Medical College of Georgia at Augusta University, 1120 15th Street, CA3145, Augusta, GA, 30912, USA.
Curr Hypertens Rep. 2020 Feb 3;22(2):13. doi: 10.1007/s11906-020-1018-8.
This review will provide an in-depth coverage of the epidemiological and pre-clinical literature surrounding the role of dietary protein in hypertension, with a special emphasis on the history of our work on the Dahl salt-sensitive rat.
Our studies have dedicated much effort into understanding the relationship between dietary protein and its effect on the development of salt-sensitive hypertension and renal injury. Our evidence over the last 15 years have demonstrated that both the source and amount of dietary protein can influence the severity of disease, where we have determined mechanisms related to immunity, the maternal environment during pregnancy, and more recently the gut microbiota, which significantly contribute to these diet-induced effects. Deeper understanding of these dietary protein-related mechanisms may provide insight on the plausibility of dietary modifications as future therapeutic avenues for hypertension and renal disease.
本综述将深入探讨围绕膳食蛋白质在高血压中作用的流行病学和临床前文献，特别强调我们对 Dahl 盐敏感大鼠的研究历程。
我们的研究投入了大量精力来理解膳食蛋白质与其对盐敏感性高血压和肾损伤发展影响之间的关系。过去 15 年我们的证据表明，膳食蛋白质的来源和量均可影响疾病严重程度，我们已确定了与免疫、孕期母体环境以及最近的肠道微生物群相关的机制，这些机制对这些饮食诱导的效应有显著影响。对这些与膳食蛋白质相关机制的更深入理解可能为将饮食调整作为高血压和肾病未来治疗途径的合理性提供见解。
