Ljungman P, Lönnqvist B, Gahrton G, Ringdén O, Wahren B
Blood. 1986 Jul;68(1):108-12.
With new techniques 19 bone marrow transplant (BMT) recipients were monitored for lymphocyte proliferation and specific IgG production in vitro by cytomegalovirus (CMV) antigen in solid phase. Twelve patients got a reactivated CMV infection as defined by virus isolation or serum IgG conversion. Lymphocyte proliferation and in vitro IgG production responses were significantly stronger in these 12 patients than in seven without ongoing CMV infection (P = .02). CMV infection was indicated by the lymphocyte responses at a mean of 45 days after BMT as against a mean of 79 days that passed before CMV growth in culture was detected (P less than .05). Lymphocyte proliferation and in vitro IgG production may thus be used as tools for diagnosis and for monitoring of CMV infections in BMT recipients.
采用新技术对19例骨髓移植（BMT）受者进行监测，通过固相巨细胞病毒（CMV）抗原检测其体外淋巴细胞增殖及特异性IgG产生情况。12例患者出现了经病毒分离或血清IgG转换定义的CMV再激活感染。这12例患者的淋巴细胞增殖及体外IgG产生反应显著强于7例未发生持续性CMV感染的患者（P = 0.02）。BMT后平均45天的淋巴细胞反应提示CMV感染，而检测到CMV在培养物中生长之前平均经过了79天（P < 0.05）。因此，淋巴细胞增殖及体外IgG产生可作为诊断和监测BMT受者CMV感染的工具。
