Matsuda Hiroki
Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Sendai, Japan.
Department of Biomedical Sciences, College of Life Sciences, Ritsumeikan University, Kusatsu, Japan.
Dev Growth Differ. 2018 Aug;60(6):393-399. doi: 10.1111/dgd.12565.
Pancreatic β cells produce insulin and play a central role in glucose homeostasis. The regenerative capacity of mammalian β cells is limited, so that loss and dysfunction of β cells causes diabetes. Zebrafish have a pancreas which is functionally and morphologically conserved with human pancreas. Zebrafish have high regenerative capacity of islets. In the present review, development of zebrafish pancreas was described in comparison to that of mammals, and the regenerative process of zebrafish pancreas was also described. This review will give information on understanding islet and pancreatic β cell development and regeneration and provide possibilities of zebrafish research for developing new diabetic therapies and regenerative medicines.
胰腺β细胞产生胰岛素，并在葡萄糖稳态中发挥核心作用。哺乳动物β细胞的再生能力有限，因此β细胞的丢失和功能障碍会导致糖尿病。斑马鱼的胰腺在功能和形态上与人类胰腺相似。斑马鱼的胰岛具有很高的再生能力。在本综述中，将斑马鱼胰腺的发育与哺乳动物的进行了比较，并描述了斑马鱼胰腺的再生过程。这篇综述将为理解胰岛和胰腺β细胞的发育与再生提供信息，并为斑马鱼研究开发新的糖尿病治疗方法和再生药物提供可能性。
