巴西中西部地区吸食 crack cocaine 的人群中戊型肝炎病毒感染的证据。
Evidence of hepatitis E virus infections among persons who use crack cocaine from the Midwest region of Brazil.
机构信息
Faculty of Pharmacy, Food and Nutrition, Federal University of Mato Grosso do Sul, Campo Grande, Brazil.
Division of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta.
出版信息
J Med Virol. 2019 Jan;91(1):151-154. doi: 10.1002/jmv.25288. Epub 2018 Oct 9.
The current study aimed to determine the seroprevalence of hepatitis E virus (HEV) infection among persons who use crack from Midwest region of Brazil. Sera samples from 698 users of crack, collected from November 2013 to July 2015 were tested for anti-HEV immunoglobulin G (IgG) and immunoglobulin M (IgM) markers. Of the 698 serum samples, 99 (14.2%) were positive for anti-HEV IgG. Two samples were positive for anti-HEV IgM but both were negative for HEV RNA. The variables independently associated with anti-HEV positivity were increasing age and absence of stable partnership. This study showed high prevalence of past hepatitis E virus infection among persons who use crack.
本研究旨在确定巴西中西部地区吸食 crack 的人群中戊型肝炎病毒 (HEV) 感染的血清流行率。2013 年 11 月至 2015 年 7 月期间收集了 698 名 crack 用户的血清样本，检测抗-HEV 免疫球蛋白 G (IgG) 和免疫球蛋白 M (IgM) 标志物。在 698 份血清样本中，99 份（14.2%）抗-HEV IgG 阳性。有 2 份样本抗-HEV IgM 阳性，但均为 HEV RNA 阴性。与抗-HEV 阳性相关的独立变量是年龄增长和没有稳定的伴侣关系。本研究显示，吸食 crack 的人群中过去戊型肝炎病毒感染的流行率较高。
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