Departamento de Inmunobioquímica, Instituto Nacional de Perinatología "Isidro Espinosa de los Reyes" (INPerIER), Ciudad de México, México.
Departamento de Tococirugía, INPerIER, Ciudad de México, México.
J Cell Mol Med. 2018 Nov;22(11):5748-5752. doi: 10.1111/jcmm.13824. Epub 2018 Aug 22.
The extracellular heat shock proteins (eHsp) family act as molecular chaperones regulating folding, transporting protein and are associated with immune modulation in different physiological and pathological processes. They have been localized in different gestational tissues and their concentration in amniotic fluid and serum has been determined. In the present study, we proposed to determine the concentration of eHsp-60, -70, IL-1β and TNFα in the serum of pregnant patients with 34 weeks of gestation with and without clinical evidences of preeclampsia (PE). Our results indicate significant increase of these markers in patients with PE with respect to healthy pregnant patients without active labor. Finally, the concentration of eHsp-60 and -70 correlated positively with the hepatic dysfunction markers uric acid, lactate dehydrogenase (LDH), glutamic oxaloacetic transaminase (GOT) glutamic pyruvic transaminase (GPT), and inflammatory IL-1β and TNFα response. In conclusion, our results demonstrate a strong associated between Hsp and marker of hepatic dysfunction.
细胞外热休克蛋白（eHsp）家族作为分子伴侣，调节蛋白质的折叠和运输，并与不同生理和病理过程中的免疫调节有关。它们已在不同的妊娠组织中定位，并确定了其在羊水和血清中的浓度。在本研究中，我们提出在 34 周妊娠且有或无子痫前期（PE）临床证据的孕妇血清中测定 eHsp-60、-70、IL-1β 和 TNFα 的浓度。我们的结果表明，与无活跃分娩的健康孕妇相比，PE 患者的这些标志物显著增加。最后，eHsp-60 和-70 的浓度与肝功能障碍标志物尿酸、乳酸脱氢酶（LDH）、谷草转氨酶（GOT）、谷丙转氨酶（GPT）以及炎症反应的 IL-1β 和 TNFα 呈正相关。总之，我们的结果表明 Hsp 与肝功能障碍标志物之间存在强烈关联。
