炎症性肠病的成像特异性介质研究进展。
Advances in Imaging Specific Mediators of Inflammatory Bowel Disease.
机构信息
Centre for Nutrition and GI Diseases, Adelaide Medical School, University of Adelaide and South Australian Health and Medical Research Institute, Adelaide 5000, Australia.
出版信息
Int J Mol Sci. 2018 Aug 21;19(9):2471. doi: 10.3390/ijms19092471.
Abstract
Inflammatory bowel disease (IBD) is characterized by chronic remitting and relapsing inflammation of the lower gastrointestinal tract. The etiology underlying IBD remains unknown, but it is thought to involve a hypersensitive immune response to environmental antigens, including the microbiota. Diagnosis and monitoring of IBD is heavily reliant on endoscopy, which is invasive and does not provide information regarding specific mediators. This review describes recent developments in imaging of IBD with a focus on positron emission tomography (PET) and single-photon emission computed tomography (SPECT) of inflammatory mediators, and how these developments may be applied to the microbiota.
摘要
炎症性肠病（IBD）的特征是下胃肠道的慢性缓解和复发炎症。IBD 的病因仍然未知，但据认为涉及对环境抗原（包括微生物群）的过敏免疫反应。IBD 的诊断和监测严重依赖于内窥镜检查，内窥镜检查具有侵入性，并且不提供关于特定介质的信息。本综述描述了 IBD 成像的最新进展，重点是炎症介质的正电子发射断层扫描（PET）和单光子发射计算机断层扫描（SPECT），以及这些进展如何应用于微生物群。
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