Ammann A J, Levy J
Clin Immunol Immunopathol. 1986 Jul;40(1):122-7. doi: 10.1016/0090-1229(86)90075-9.
Unique laboratory abnormalities, found in pediatric patients with clinical features of immunodeficiency, led to the original observation that a syndrome of acquired immunodeficiency (AIDS) was also occurring in pediatric populations. Initial observations which demonstrated the nonspecific findings of polyclonal hypergammaglobulinemia and T-cell deficiency were followed by confirmatory findings when testing for the AIDS retrovirus became available. In the pediatric population availability of antibody testing and viral isolation became critical in differentiating primary immunodeficiency disorders which involved both the B- and T-cell systems from AIDS associated with retrovirus infection. At this time based upon clinical, epidemiologic, immunologic, and serologic studies, the syndrome of pediatric AIDS can be distinguished from other primary and secondary pediatric immunodeficiency disorders.
在具有免疫缺陷临床特征的儿科患者中发现的独特实验室异常，引发了最初的观察，即获得性免疫缺陷综合征（AIDS）也在儿科人群中出现。最初观察到多克隆高丙种球蛋白血症和T细胞缺陷等非特异性表现，随后在可进行艾滋病逆转录病毒检测时得到了证实。在儿科人群中，抗体检测和病毒分离对于区分涉及B细胞和T细胞系统的原发性免疫缺陷疾病与与逆转录病毒感染相关的艾滋病至关重要。此时，基于临床、流行病学、免疫学和血清学研究，儿科艾滋病综合征可与其他原发性和继发性儿科免疫缺陷疾病区分开来。
