Ammann A J, Wara D W, Cowan M J
Ann N Y Acad Sci. 1984;437:340-9. doi: 10.1111/j.1749-6632.1984.tb37154.x.
Approximately 40 to 50 infants and children with similar epidemiologic, clinical, and laboratory features of AIDS have been described. The occurrence of significant numbers of patients with PAIDS in geographic areas that are associated with similar risk factors and clinical features of AIDS suggests a common cause. Immunologic evaluation reveals hypergammaglobulinemia, decreased or absent antibody responses after immunization, normal to decreased T-cell numbers, decreased helper/suppressor cell ratios, and abnormal results of functional studies of T-cells. None of the patients described has the clinical or laboratory features of well-established congenital immunodeficiency disorders. No consistent viral agent has been documented except for antibody to ARV and HTLV III. The frequent finding of T-cell abnormalities in the mothers of infants with PAIDS is in contrast to the absence of such abnormalities in the mothers of infants with congenital immunodeficiency disorders. Future studies in PAIDS should be directed toward uncovering the etiology and risk factors as well as determining the response to treatment with various methods of immunologic reconstitution.
已描述了约40至50名具有类似艾滋病流行病学、临床和实验室特征的婴幼儿。在与艾滋病类似风险因素和临床特征相关的地理区域出现大量小儿艾滋病患者，提示存在共同病因。免疫评估显示有高球蛋白血症、免疫接种后抗体反应降低或缺失、T细胞数量正常至减少、辅助/抑制细胞比例降低以及T细胞功能研究结果异常。所描述的患者均无已确诊的先天性免疫缺陷疾病的临床或实验室特征。除了抗猿猴病毒和人类嗜T淋巴细胞病毒III型抗体外，未记录到一致的病毒病原体。小儿艾滋病患儿母亲中频繁发现T细胞异常，这与先天性免疫缺陷疾病患儿母亲中未出现此类异常形成对比。未来对小儿艾滋病的研究应致力于揭示病因和风险因素，以及确定采用各种免疫重建方法治疗的反应。
